Ferroptosis is a type of regulated cell death characterized by intracellular accumulation of
iron and reactive oxygen species, inhibition of system Xc-, glutathione depletion …

Ischemic stroke caused by arterial occlusion is the most common type of stroke, which is
among the most frequent causes of disability and death worldwide. Current treatment …

Iron, an essential mineral in the body, is involved in numerous physiological processes,
making the maintenance of iron homeostasis crucial for overall health. Both iron overload …

Emerging evidence suggests that ferroptosis, a unique regulated cell death modality that is
morphologically and mechanistically different from other forms of cell death, plays a vital role …

Ferroptosis is a new type of cell death that was discovered in recent years and is usually
accompanied by a large amount of iron accumulation and lipid peroxidation during the cell …

Acyl-CoA synthetase long-chain family member 4 (ACSL4) is an important isozyme for
polyunsaturated fatty acids (PUFAs) metabolism that dictates ferroptosis sensitivity. The role …

Ischemic stroke caused by intracranial vascular occlusion has become increasingly
prevalent with considerable mortality and disability, which gravely burdens the global …

Ferroptosis plays a critical role in ischemic stroke, and anti-ferroptosis strategies were
regarded as potentially effective measures. Based on ferroptosis-related mechanisms, this …

Ischemic stroke (IS) is one of the most fatal diseases. Neuroimmunity, inflammation, and
oxidative stress play important roles in various complex mechanisms of IS. In particular, the …

Over 30 million people suffer from the consequences of ischemic stroke. The precise
molecular mechanism of neuronal damage during ischemic stroke remains unclear; …