The tubulin code, from molecules to health and disease
ED McKenna, SL Sarbanes… - Annual Review of …, 2023 - annualreviews.org
Microtubules are essential dynamic polymers composed of α/β-tubulin heterodimers. They
support intracellular trafficking, cell division, cellular motility, and other essential cellular …
support intracellular trafficking, cell division, cellular motility, and other essential cellular …
The DYRK family of kinases in cancer: molecular functions and therapeutic opportunities
DYRK (dual-specificity tyrosine-regulated kinases) are an evolutionary conserved family of
protein kinases with members from yeast to humans. In humans, DYRKs are pleiotropic …
protein kinases with members from yeast to humans. In humans, DYRKs are pleiotropic …
A multiplex human pluripotent stem cell platform defines molecular and functional subclasses of autism-related genes
Autism is a clinically heterogeneous neurodevelopmental disorder characterized by
impaired social interactions, restricted interests, and repetitive behaviors. Despite significant …
impaired social interactions, restricted interests, and repetitive behaviors. Despite significant …
The omnipresence of DYRK1A in human diseases
The increasing population will challenge healthcare, particularly because the worldwide
population has never been older. Therapeutic solutions to age-related disease will be …
population has never been older. Therapeutic solutions to age-related disease will be …
Dyrk1a from Gene Function in Development and Physiology to Dosage Correction across Life Span in Down Syndrome
H Atas-Ozcan, V Brault, A Duchon, Y Herault - Genes, 2021 - mdpi.com
Down syndrome is the main cause of intellectual disabilities with a large set of comorbidities
from developmental origins but also that appeared across life span. Investigation of the …
from developmental origins but also that appeared across life span. Investigation of the …
What we can learn from a genetic rodent model about autism
Autism spectrum disorders (ASD) are complex neurodevelopmental disorders that are
caused by genetic and/or environmental impacts, often probably by the interaction of both …
caused by genetic and/or environmental impacts, often probably by the interaction of both …
Social motivation a relative strength in DYRK1A syndrome on a background of significant speech and language impairments
Speech and language impairments are commonly reported in DYRK1A syndrome. Yet,
speech and language abilities have not been systematically examined in a prospective …
speech and language abilities have not been systematically examined in a prospective …
Integrative approach to interpret DYRK1A variants, leading to a frequent neurodevelopmental disorder
Purpose DYRK1A syndrome is among the most frequent monogenic forms of intellectual
disability (ID). We refined the molecular and clinical description of this disorder and …
disability (ID). We refined the molecular and clinical description of this disorder and …
Dyrk1a gene dosage in glutamatergic neurons has key effects in cognitive deficits observed in mouse models of MRD7 and Down syndrome
V Brault, TL Nguyen, J Flores-Gutiérrez, G Iacono… - PLoS …, 2021 - journals.plos.org
Perturbation of the excitation/inhibition (E/I) balance leads to neurodevelopmental diseases
including to autism spectrum disorders, intellectual disability, and epilepsy. Loss-of-function …
including to autism spectrum disorders, intellectual disability, and epilepsy. Loss-of-function …
A perspective on molecular signalling dysfunction, its clinical relevance and therapeutics in autism spectrum disorder
Intellectual disability (ID) and autism spectrum disorder (ASD) are neurodevelopmental
disorders that have become a primary clinical and social concern, with a prevalence of 2 …
disorders that have become a primary clinical and social concern, with a prevalence of 2 …