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Epidemiology of brain metastases and leptomeningeal disease
Brain metastases affect a significant percentage of patients with advanced extracranial
malignancies. Yet, the incidence of brain metastases remains poorly described, largely due …
malignancies. Yet, the incidence of brain metastases remains poorly described, largely due …
A view on drug resistance in cancer
The problem of resistance to therapy in cancer is multifaceted. Here we take a reductionist
approach to define and separate the key determinants of drug resistance, which include …
approach to define and separate the key determinants of drug resistance, which include …
Treatment for brain metastases: ASCO-SNO-ASTRO guideline
MA Vogelbaum, PD Brown, H Messersmith… - 2022 - academic.oup.com
Purpose To provide guidance to clinicians regarding therapy for patients with brain
metastases from solid tumors. Methods ASCO convened an Expert Panel and conducted a …
metastases from solid tumors. Methods ASCO convened an Expert Panel and conducted a …
[HTML][HTML] EANO–ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up of patients with brain metastasis from solid tumours
Highlights•This Clinical Practice Guideline provides management recommendations for
patients with brain metastases from solid tumours.•The guideline covers clinical and …
patients with brain metastases from solid tumours.•The guideline covers clinical and …
Radiation therapy for brain metastases: an ASTRO clinical practice guideline
Purpose This guideline provides updated evidence-based recommendations addressing
recent developments in the management of patients with brain metastases, including …
recent developments in the management of patients with brain metastases, including …
Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2019 for the treatment of colorectal cancer
Y Hashiguchi, K Muro, Y Saito, Y Ito, Y Ajioka… - International journal of …, 2020 - Springer
The number of deaths from colorectal cancer in Japan continues to increase. Colorectal
cancer deaths exceeded 50,000 in 2016. In the 2019 edition, revision of all aspects of …
cancer deaths exceeded 50,000 in 2016. In the 2019 edition, revision of all aspects of …
Stereotactic ablative radiotherapy versus standard of care palliative treatment in patients with oligometastatic cancers (SABR-COMET): a randomised, phase 2, open …
Background The oligometastatic paradigm suggests that some patients with a limited
number of metastases might be cured if all lesions are eradicated. Evidence from …
number of metastases might be cured if all lesions are eradicated. Evidence from …
Brain metastases
An estimated 20% of all patients with cancer will develop brain metastases, with the majority
of brain metastases occurring in those with lung, breast and colorectal cancers, melanoma …
of brain metastases occurring in those with lung, breast and colorectal cancers, melanoma …
Central nervous system cancers, version 3.2020, NCCN clinical practice guidelines in oncology
The NCCN Guidelines for Central Nervous System (CNS) Cancers focus on management of
adult CNS cancers ranging from noninvasive and surgically curable pilocytic astrocytomas …
adult CNS cancers ranging from noninvasive and surgically curable pilocytic astrocytomas …
Survival in patients with brain metastases: summary report on the updated diagnosis-specific graded prognostic assessment and definition of the eligibility quotient
PURPOSE Conventional wisdom has rendered patients with brain metastases ineligible for
clinical trials for fear that poor survival could mask the benefit of otherwise promising …
clinical trials for fear that poor survival could mask the benefit of otherwise promising …