This review examines intermittent target search strategies, which combine phases of slow
motion, allowing the searcher to detect the target, and phases of fast motion during which …

Bacterial genomes are remarkably stable from one generation to the next but are plastic on
an evolutionary time scale, substantially shaped by horizontal gene transfer, genome …

Combining extensive single particle tracking microscopy data of endogenous lipid granules
in living fission yeast cells with analytical results we show evidence for anomalous diffusion …

A number of vital biological processes rely on fast and precise recognition of a specific DNA
sequence (site) by a protein. How can a protein find its site on a long DNA molecule among …

We present a general theory which allows one to accurately evaluate the mean first-passage
time (FPT) for regular random walks in bounded domains, and its extensions to related first …

It has long been appreciated that the transport properties of molecules can control reaction
kinetics. This effect can be characterized by the time it takes a diffusing molecule to reach a …

Coordinated regulation of gene expression relies on transcription factors (TFs) binding to
specific DNA sites. Our large-scale information–theoretical analysis of> 950 TF-binding …

When does a diffusing particle reach its target for the first time? This first-passage time (FPT)
problem is central to the kinetics of molecular reactions in chemistry and molecular biology …

The enormous size of mammalian genomes means that for a DNA-binding protein the
number of nonspecific, off-target sites vastly exceeds the number of specific, cognate sites …

Operons (clusters of co-regulated genes with related functions) are common features of
bacterial genomes. More recently, functional gene clustering has been reported in …