The canonical role of the hemostatic and fibrinolytic systems is to maintain vascular integrity.
Perturbations in either system can prompt primary pathological end points of hemorrhage or …

Growing lines of evidence recognize that platelets play a central role in liver homeostasis
and pathobiology. Platelets have important roles at every stage during the continuum of liver …

Liver is the primary source of numerous proteins that are critical for normal function of the
blood coagulation cascade. Because of this, diseases of the liver, particularly when affiliated …

Platelets play a pivotal role in stimulating liver regeneration after partial hepatectomy in
rodents and humans. Liver regeneration in rodents is delayed when platelets are inhibited …

Platelets are key players in thrombosis and hemostasis. Alterations in platelet count and
function are common in liver disease, and may contribute to bleeding or thrombotic …

Molecular magnetic resonance (MR) imaging utilizes molecular probes to provide added
biochemical or cellular information to what can already be achieved with anatomical and …

Innate immunity can initiate platelet activation during the development of thrombosis through
a process, termed immunothrombosis. Neutrophils form neutrophil extracellular traps (NETs) …

Fibrosis is an unavoidable consequence of chronic inflammation. Extracellular matrix
deposition by fibroblasts, stimulated by multiple pathways, is the first step in the onset of …

Platelets have classically been considered crucial effector cells in hemostasis, but now are
increasingly recognized as players during inflammatory responses in innate and adaptive …

Acetaminophen (APAP)-induced liver injury in humans is associated with robust coagulation
cascade activation and thrombocytopenia. However, it is not known whether coagulation …