Alcoholic beverages, and the problems they engender, have been familiar fixtures in human
societies since the beginning of recorded history. We review advances in alcohol science in …

Alcoholic liver disease (ALD) is the most prevalent type of chronic liver disease worldwide.
ALD can progress from alcoholic fatty liver (AFL) to alcoholic steatohepatitis (ASH), which is …

Alcohol use disorder (AUD) is a highly prevalent but severely under-treated disorder, with
only three widely-approved pharmacotherapies. Given that AUD is a very heterogeneous …

We review the evidence on effectiveness of interventions for the treatment and prevention of
selected mental disorders in low-income and middle-income countries. Depression can be …

Health care decisions are increasingly being made on research-based evidence rather than
on expert opinion or clinical experience alone. Systematic reviews represent a rigorous …

Background Alcohol dependence belongs to the globally leading health risk factors.
Therapeutic success of psychosocial programs for relapse prevention is moderate and could …

Since 1975, Robert Julien's A Primer of Drug Action has been the definitive guide to the
effects of psychoactive drugs on the brain and on behavior. Now fully updated, this popular …

The initial wave of the baby boom generation turned 65 years old in 2011, a generation that
comprises 30% of the total US population. 1 The size of this generation and their longer life …

During the last decade there has been an unprecedented expansion of legalized gambling
throughout North America. Three primary forces appear to be motivating this growth:(1) the …

Aims Although debates over the efficacy of oral naltrexone and acamprosate in treating
alcohol use disorders tend to focus on their global efficacy relative to placebo or their …