[HTML][HTML] Cognitive impairment associated with cancer: a brief review

JC Pendergrass, SD Targum… - Innovations in clinical …, 2018 - ncbi.nlm.nih.gov
This brief review explores the areas of cognitive impairment that have been observed in
cancer patients and survivors, the cognitive assessment tools used, and the management of …

Radiation-induced brain injury: a review

D Greene-Schloesser, ME Robbins, AM Peiffer… - Frontiers in …, 2012 - frontiersin.org
Approximately 100,000 primary and metastatic brain tumor patients/year in the US survive
long enough (> 6 months) to experience radiation-induced brain injury. Prior to 1970, the …

Hippocampal avoidance during whole-brain radiotherapy plus memantine for patients with brain metastases: phase III trial NRG oncology CC001

PD Brown, V Gondi, S Pugh, WA Tome… - Journal of Clinical …, 2020 - ascopubs.org
PURPOSE Radiation dose to the neuroregenerative zone of the hippocampus has been
found to be associated with cognitive toxicity. Hippocampal avoidance (HA) using intensity …

Preservation of memory with conformal avoidance of the hippocampal neural stem-cell compartment during whole-brain radiotherapy for brain metastases (RTOG …

V Gondi, SL Pugh, WA Tome, C Caine… - Journal of Clinical …, 2014 - ascopubs.org
Purpose Hippocampal neural stem-cell injury during whole-brain radiotherapy (WBRT) may
play a role in memory decline. Intensity-modulated radiotherapy can be used to avoid …

Délinéation des organes à risque et contraintes dosimétriques

G Noël, D Antoni, I Barillot, B Chauvet - Cancer/Radiothérapie, 2016 - Elsevier
Résumé À partir d'une revue de la littérature, cet article définit les limites de délinéation pour
les organes critiques, puis les contraintes de dose sur ces derniers lorsque la radiothérapie …

Randomized phase III trial of prophylactic cranial irradiation with or without hippocampal avoidance for small-cell lung cancer (PREMER): a GICOR-GOECP-SEOR …

N Rodríguez de Dios, F Couñago… - Journal of Clinical …, 2021 - ascopubs.org
PURPOSE Radiation dose received by the neural stem cells of the hippocampus during
whole-brain radiotherapy has been associated with neurocognitive decline. The key …

[HTML][HTML] Phase 3 randomized trial of prophylactic cranial irradiation with or without hippocampus avoidance in SCLC (NCT01780675)

JSA Belderbos, DKM De Ruysscher… - Journal of Thoracic …, 2021 - Elsevier
Introduction To compare neurocognitive functioning in patients with SCLC who received
prophylactic cranial irradiation (PCI) with or without hippocampus avoidance (HA). Methods …

Senolytics and senostatics as adjuvant tumour therapy

S Short, E Fielder, S Miwa, T von Zglinicki - EBioMedicine, 2019 - thelancet.com
Cell senescence is a driver of ageing, frailty, age-associated disease and functional decline.
In oncology, tumour cell senescence may contribute to the effect of adjuvant therapies, as it …

Organs at risk in the brain and their dose-constraints in adults and in children: a radiation oncologist's guide for delineation in everyday practice

S Scoccianti, B Detti, D Gadda, D Greto, I Furfaro… - Radiotherapy and …, 2015 - Elsevier
Purpose Accurate organs at risk definition is essential for radiation treatment of brain tumors.
The aim of this study is to provide a stepwise and simplified contouring guide to delineate …

A prospective phase II randomized trial of proton radiotherapy vs intensity-modulated radiotherapy for patients with newly diagnosed glioblastoma

PD Brown, C Chung, DD Liu, S McAvoy… - Neuro …, 2021 - academic.oup.com
Background To determine if proton radiotherapy (PT), compared to intensity-modulated
radiotherapy (IMRT), delayed time to cognitive failure in patients with newly diagnosed …