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Risk of metabolic abnormalities in osteoarthritis: a new perspective to understand its pathological mechanisms
Although aging has traditionally been viewed as the most important risk factor for
osteoarthritis (OA), an increasing amount of epidemiological evidence has highlighted the …
osteoarthritis (OA), an increasing amount of epidemiological evidence has highlighted the …
[HTML][HTML] Chondroprotective effects of Apolipoprotein D in knee osteoarthritis mice through the PI3K/AKT/mTOR signaling pathway
G Zhang, C Huang, R Wang, J Guo, Y Qin… - International …, 2024 - Elsevier
Background Because the pathophysiology of osteoarthritis (OA) has not been fully
elucidated, targeted treatments are lacking. In this study, we assessed the role and …
elucidated, targeted treatments are lacking. In this study, we assessed the role and …
Proteomic profiling of extracellular vesicles in synovial fluid and plasma from Oligoarticular Juvenile Idiopathic Arthritis patients reveals novel immunopathogenic …
Introduction New early low-invasive biomarkers are demanded for the management of
Oligoarticular Juvenile Idiopathic Arthritis (OJIA), the most common chronic pediatric …
Oligoarticular Juvenile Idiopathic Arthritis (OJIA), the most common chronic pediatric …
Protein N-glycosylation aberrations and glycoproteomic network alterations in osteoarthritis and osteoarthritis with type 2 diabetes
Y Luo, Z Wu, S Chen, H Luo, X Mo, Y Wang, J Tang - Scientific Reports, 2022 - nature.com
Whether the relationship between type 2 diabetes mellitus (T2DM) and osteoarthritis (OA)
can be solely attributed to the shared risk factors, such as obesity, remains controversial …
can be solely attributed to the shared risk factors, such as obesity, remains controversial …
[HTML][HTML] Proteomic profiling of human menisci from mild joint degeneration and end-stage osteoarthritis versus healthy controls
R Paz-González, A Turkiewicz, N Ali… - … and Cartilage Open, 2023 - Elsevier
Objective To gain new insight into the molecular changes of the meniscus by comparing the
proteome profiles of healthy controls with mild degeneration and end-stage osteoarthritis …
proteome profiles of healthy controls with mild degeneration and end-stage osteoarthritis …
Identification of osteoarthritis-characteristic genes and immunological micro-environment features through bioinformatics and machine learning-based approaches
Z Da, R Guo, J Sun, A Wang - BMC Medical Genomics, 2023 - Springer
Background Osteoarthritis (OA) is a multifaceted chronic joint disease characterized by
complex mechanisms. It has a detrimental impact on the quality of life for individuals in the …
complex mechanisms. It has a detrimental impact on the quality of life for individuals in the …
Identification of susceptibility modules and hub genes of osteoarthritis by WGCNA analysis
Y Wang, W Zhou, Y Chen, D He, Z Qin, Z Wang… - Frontiers in …, 2022 - frontiersin.org
Osteoarthritis (OA) is a major cause of pain, disability, and social burden in the elderly
throughout the world. Although many studies focused on the molecular mechanism of OA, its …
throughout the world. Although many studies focused on the molecular mechanism of OA, its …
The potential molecular markers of inflammatory response in KOA with AD based on single-cell transcriptome sequencing analysis and identification of ligands by …
Y Wu, W Chen, J Jian, W Liu, H Wang, D Gao, W Liu - Molecular Diversity, 2024 - Springer
Alzheimer's disease (AD) and osteoarthritis (OA) are both senile degenerative diseases.
Clinical studies have found that OA patients have a significantly increased risk of AD in their …
Clinical studies have found that OA patients have a significantly increased risk of AD in their …
APOD acts on fibroblast‐like synoviocyte and chondrocyte to alleviate the process of osteoarthritis in vitro
W Xu, S Gu, G Zhang, R Wang, S Lv… - Journal of …, 2024 - Wiley Online Library
The pathogenesis of osteoarthritis (OA) is still unclear, leading to the lack of targeted
treatment. We aimed to probe into the effect of apolipoprotein D (APOD), the key gene from …
treatment. We aimed to probe into the effect of apolipoprotein D (APOD), the key gene from …
A novel serological biomarker are associated with disease severity in patients with osteoarthritis
B Li, H Zhan, J Luo, X Wang, T Cao, B Wei - Journal of Bone and Mineral …, 2022 - Springer
Background and aim Apolipoprotein D (ApoD) is a 25–30 kDa glycoprotein, as a distinct
component of the human plasma lipoprotein system. Its known biological functions are …
component of the human plasma lipoprotein system. Its known biological functions are …