Tuberculosis (TB) in humans is characterized by formation of immune-rich granulomas in
infected tissues, the architecture and composition of which are thought to affect disease …

Overfitting describes the phenomenon where a highly predictive model on the training data
generalizes poorly to future observations. It is a common concern when applying machine …

The increasing use of high-throughput gene expression quantification technologies over the
last two decades and the fact that most of the published studies are stored in public …

Several studies have shown that the pre-vaccination immune state is associated with the
antibody response to vaccination. However, the generalizability and mechanisms that …

Dysregulation of the immune response to bacterial infection can lead to sepsis, a condition
with high mortality. Multiple whole-blood gene-expression studies have defined sepsis …

Multiple cancers regulate oxidative stress by activating the transcription factor NRF2 through
mutation of its negative regulator, KEAP1. NRF2 has been studied extensively in KEAP1 …

Immunological health has been challenging to characterize but could be defined as the
absence of immune pathology. While shared features of some immune diseases and the …

Most infections with Mycobacterium tuberculosis (Mtb) manifest as a clinically asymptomatic,
contained state, known as latent tuberculosis infection, that affects approximately one …

Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is a global cause of death.
Granuloma-associated lymphoid tissue (GrALT) correlates with protection during TB, but the …

Improved tuberculosis diagnostics and tools for monitoring treatment response are urgently
needed. We developed a robust and simple, PCR-based host-blood transcriptomic …