Water and adhesives have a conflicting relationship as demonstrated by the failure of most
man-made adhesives in underwater environments. However, living creatures routinely …

Biomolecular condensation processes are increasingly recognized as a fundamental
mechanism that living cells use to organize biomolecules in time and space. These …

The MobiDB database (URL: https://mobidb. org/) is a knowledge base of intrinsically
disordered proteins. MobiDB aggregates disorder annotations derived from the literature …

Optimum protein function and biochemical activity critically depends on water availability
because solvent thermodynamics drive protein folding and macromolecular interactions …

Elucidating the wiring diagram of the human cell is a central goal of the postgenomic era.
We combined genome engineering, confocal live-cell imaging, mass spectrometry, and data …

Compartmentalization is an essential feature of eukaryotic life and is achieved both via
membrane-bound organelles, such as mitochondria, and membrane-less biomolecular …

Understanding intracellular phase separation is crucial for deciphering transcriptional
control, cell fate transitions, and disease mechanisms. However, the key residues, which …

Background The liquid–liquid phase separation (LLPS) of biomolecules in cell underpins
the formation of membraneless organelles, which are the condensates of protein, nucleic …

A wide range of proteins have been reported to condensate into a dense liquid phase,
forming a reversible droplet state. Failure in the control of the droplet state can lead to the …

Phase separation inside mammalian cells regulates the formation of the biomolecular
condensates that are related to gene expression, signalling, development and disease …