It has been proposed that a chronic state of inflammation correlated with aging known as
inflammaging, is implicated in multiple disease states commonly observed in the elderly …

In the last decade, pathway-specific targeted therapy has revolutionized colorectal cancer
(CRC) treatment strategies. This type of therapy targets a tumor-vulnerable spot formed …

During the past decade, an abundance of new evidence highlighted the importance of
inflammation in the development of chronic pathologies such as neurodegeneration, cancer …

The phosphatidylinositol-3-kinase (PI3K)/Akt and the mammalian target of rapamycin
(mTOR) signaling pathways are two pathways crucial to many aspects of cell growth and …

Simple Summary PI3K signaling pathway plays an essential role in many cellular processes
and is frequently altered in breast cancer, leading to increased tumor growth and reduced …

Highlights•Preclinical studies support us of PI3K inhibitors in autoimmunity and
inflammation.•First in class PI3K inhibitor has been approved for treatment of B cell …

Renal cell carcinoma (RCC) represents 85–95% of kidney cancers and is the most frequent
type of renal cancer in adult patients. It accounts for 3% of all cancer cases and is in 7th …

Abstract Phosphatidylinositol 3-kinases (PI3Ks) are lipid kinases that regulate diverse
cellular processes including proliferation, adhesion, survival, and motility. Dysregulated …

Unsustained enzyme inhibition is a barrier to targeted therapy for cancer. Here, resistance to
a class I PI3K inhibitor in a model of metastatic breast cancer driven by PI3K and MYC was …

Autophagy is an evolutionarily conserved and exquisitely regulated self-eating cellular
process with important biological functions. Phosphatidylinositol 3-kinases (PtdIns3Ks) and …