Cell-based therapeutics are an emerging modality with the potential to treat many currently
intractable diseases through uniquely powerful modes of action. Despite notable recent …

The generation of islet-like endocrine clusters from human pluripotent stem cells (hPSCs)
has the potential to provide an unlimited source of insulin-producing β cells for the treatment …

Insulin-producing β cells created from human pluripotent stem cells have potential as a
therapy for insulin-dependent diabetes, but human pluripotent stem cell-derived islets (SC …

Implantable drug delivery systems (IDDS) are an attractive alternative to conventional drug
administration routes. Oral and injectable drug administration are the most common routes …

The successful transplantation of stem cells has the potential to transform regenerative
medicine approaches and open promising avenues to repair, replace, and regenerate …

Diabetes mellitus refers to a group of metabolic disorders which affect how the body uses
glucose impacting approximately 9% of the population worldwide. This review covers the …

How cells become specialized, or" mature," is important for cell and developmental biology.
While maturity is usually deemed a terminal fate, it may be more helpful to consider …

Type 1 diabetes mellitus (T1DM) is a growing global health concern that affects
approximately 8.5 million individuals worldwide. T1DM is characterized by an autoimmune …

For the past century, insulin injections have saved millions of lives, but glycemic instability is
still a persistent challenge for people with diabetes, leading to tremendous morbidity and …

The immune isolation of cells within devices has the potential to enable long-term protein
replacement and functional cures for a range of diseases, without requiring immune …