Natural killer (NK) cells comprise a unique population of innate lymphoid cells endowed with
intrinsic abilities to identify and eliminate virally infected cells and tumour cells. Possessing …

CRISPR screens are a powerful source of biological discovery, enabling the unbiased
interrogation of gene function in a wide range of applications and species. In pooled …

Over the past decade, CRISPR has become as much a verb as it is an acronym,
transforming biomedical research and providing entirely new approaches for dissecting all …

Clustered regularly interspaced short palindromic repeats (CRISPR) system provides
adaptive immunity against plasmids and phages in prokaryotes. This system inspires the …

Summary Exhausted CD8 T (T ex) cells in chronic viral infection and cancer have sustained
co-expression of inhibitory receptors (IRs). T ex cells can be reinvigorated by blocking IRs …

Cancer cells can evade natural killer (NK) cell activity, thereby limiting anti-tumor immunity.
To reveal genetic determinants of susceptibility to NK cell activity, we examined interacting …

Purpose: Patients with advanced non–small cell lung cancer (NSCLC) harboring activating
EGFR mutations are initially responsive to tyrosine kinase inhibitors (TKI). However …

Epithelial ovarian cancer (EOC) remains one of the most lethal gynecological cancers.
Cytokine-induced memory–like (CIML) natural killer (NK) cells have shown promising results …

Despite tremendous progress in the past decade, the complex and heterogeneous nature of
cancer complicates efforts to identify new therapies and therapeutic combinations that …

Natural killer (NK) cells have clinical potential against cancer; however, multiple limitations
hinder the success of NK cell therapy. Here, we performed unbiased functional map** of …