A review on the stereospecific fate and effects of chiral conazole fungicides
L Bielská, SE Hale, L Škulcová - Science of the Total Environment, 2021 - Elsevier
The production and use of chiral pesticides are triggered by the need for more complex
molecules capable of effectively combating a greater spectrum of pests and crop diseases …
molecules capable of effectively combating a greater spectrum of pests and crop diseases …
Chiral separation of agricultural fungicides
V Pérez-Fernández, MÁ García, ML Marina - Journal of Chromatography A, 2011 - Elsevier
Fungicides are very important and diverse environmental and agricultural concern species.
Their determination in commercial formulations or environmental matrices, requires highly …
Their determination in commercial formulations or environmental matrices, requires highly …
In vitro metabolism of the emerging contaminant 6PPD-quinone in human and rat liver microsomes: Kinetics, pathways, and mechanism
YY Zhang, JW Huang, YH Liu, JN Zhang, Z Huang… - Environmental …, 2024 - Elsevier
Abstract N-(1, 3-dimethylbutyl)-N′-phenyl-p-phenylenediamine-quinone (6PPD-Q) is an
ozonation product of the rubber antioxidant N-(1, 3-dimethylbutyl)-N′-phenyl-p …
ozonation product of the rubber antioxidant N-(1, 3-dimethylbutyl)-N′-phenyl-p …
Enantiomer separation of triazole fungicides by high‐performance liquid chromatography
Z Ying, L Ling, L Kunde, Z **… - … of Molecular Asymmetry, 2009 - Wiley Online Library
Enantiomer separation is one of the most important prerequisites for the investigation of
environmental enantioselective behaviors for chiral pesticides. In the present study, the …
environmental enantioselective behaviors for chiral pesticides. In the present study, the …
Myclobutanil enantioselective risk assessment in humans through in vitro CYP450 reactions: Metabolism and inhibition studies
Myclobutanil is a chiral triazole fungicide that is employed worldwide. Although enantiomers
have the same physical-chemical properties, they may differ in terms of activity, metabolism …
have the same physical-chemical properties, they may differ in terms of activity, metabolism …
Bromuconazole-induced hepatotoxicity is accompanied by upregulation of PXR/CYP3A1 and downregulation of CAR/CYP2B1 gene expression
Despite widespread use of bromuconazole as a pesticide for food crops and fruits, limited
studies have been done to evaluate its toxic effects. Here, we evaluated the hepatotoxic …
studies have been done to evaluate its toxic effects. Here, we evaluated the hepatotoxic …
Fungicide bromuconazole has the potential to induce hepatotoxicity at the physiological, metabolomic and transcriptomic levels in rats
S Wu, X Ji, J Wang, H Wu, J Han, H Zhang, J Xu… - Environmental …, 2021 - Elsevier
Bromuconazole (BROMU), a representative triazole fungicide, has been widely used in
agriculture for its low cost and highly efficiency against various fungi. BROMU residue was …
agriculture for its low cost and highly efficiency against various fungi. BROMU residue was …
Enantioselective determination of triazole fungicide simeconazole in vegetables, fruits, and cereals using modified QuEChERS (quick, easy, cheap, effective, rugged …
J Li, F Dong, J Xu, X Liu, Y Li, W Shan, Y Zheng - Analytica chimica acta, 2011 - Elsevier
A rapid and effective method for enantioselective determination of simeconazole
enantiomers in food products (cucumber, tomato, apple, pear, wheat and rice) has been …
enantiomers in food products (cucumber, tomato, apple, pear, wheat and rice) has been …
PXR-mediated idiosyncratic drug-induced liver injury: mechanistic insights and targeting approaches
Introduction The human liver is the center for drug metabolism and detoxification and is,
therefore, constantly exposed to toxic chemicals. The loss of liver function as a result of this …
therefore, constantly exposed to toxic chemicals. The loss of liver function as a result of this …
Cross-species comparison of conazole fungicide metabolites using rat and rainbow trout (Onchorhynchus mykiss) hepatic microsomes and purified human CYP 3A4
CS Mazur, JF Kenneke - Environmental science & technology, 2008 - ACS Publications
Ecological risk assessment frequently relies on cross-species extrapolation to predict acute
toxicity from chemical exposures. A major concern for environmental risk characterization is …
toxicity from chemical exposures. A major concern for environmental risk characterization is …