A review on the stereospecific fate and effects of chiral conazole fungicides

L Bielská, SE Hale, L Škulcová - Science of the Total Environment, 2021 - Elsevier
The production and use of chiral pesticides are triggered by the need for more complex
molecules capable of effectively combating a greater spectrum of pests and crop diseases …

Chiral separation of agricultural fungicides

V Pérez-Fernández, MÁ García, ML Marina - Journal of Chromatography A, 2011 - Elsevier
Fungicides are very important and diverse environmental and agricultural concern species.
Their determination in commercial formulations or environmental matrices, requires highly …

In vitro metabolism of the emerging contaminant 6PPD-quinone in human and rat liver microsomes: Kinetics, pathways, and mechanism

YY Zhang, JW Huang, YH Liu, JN Zhang, Z Huang… - Environmental …, 2024 - Elsevier
Abstract N-(1, 3-dimethylbutyl)-N′-phenyl-p-phenylenediamine-quinone (6PPD-Q) is an
ozonation product of the rubber antioxidant N-(1, 3-dimethylbutyl)-N′-phenyl-p …

Enantiomer separation of triazole fungicides by high‐performance liquid chromatography

Z Ying, L Ling, L Kunde, Z **… - … of Molecular Asymmetry, 2009 - Wiley Online Library
Enantiomer separation is one of the most important prerequisites for the investigation of
environmental enantioselective behaviors for chiral pesticides. In the present study, the …

Myclobutanil enantioselective risk assessment in humans through in vitro CYP450 reactions: Metabolism and inhibition studies

FS Fonseca, DB Carrão, NCP de Albuquerque… - Food and Chemical …, 2019 - Elsevier
Myclobutanil is a chiral triazole fungicide that is employed worldwide. Although enantiomers
have the same physical-chemical properties, they may differ in terms of activity, metabolism …

Bromuconazole-induced hepatotoxicity is accompanied by upregulation of PXR/CYP3A1 and downregulation of CAR/CYP2B1 gene expression

DH Abdelhadya, MA El-Magd, ZI Elbialy… - Toxicology …, 2017 - Taylor & Francis
Despite widespread use of bromuconazole as a pesticide for food crops and fruits, limited
studies have been done to evaluate its toxic effects. Here, we evaluated the hepatotoxic …

Fungicide bromuconazole has the potential to induce hepatotoxicity at the physiological, metabolomic and transcriptomic levels in rats

S Wu, X Ji, J Wang, H Wu, J Han, H Zhang, J Xu… - Environmental …, 2021 - Elsevier
Bromuconazole (BROMU), a representative triazole fungicide, has been widely used in
agriculture for its low cost and highly efficiency against various fungi. BROMU residue was …

Enantioselective determination of triazole fungicide simeconazole in vegetables, fruits, and cereals using modified QuEChERS (quick, easy, cheap, effective, rugged …

J Li, F Dong, J Xu, X Liu, Y Li, W Shan, Y Zheng - Analytica chimica acta, 2011 - Elsevier
A rapid and effective method for enantioselective determination of simeconazole
enantiomers in food products (cucumber, tomato, apple, pear, wheat and rice) has been …

PXR-mediated idiosyncratic drug-induced liver injury: mechanistic insights and targeting approaches

J Wang, M Bwayi, RRF Gee, T Chen - Expert opinion on drug …, 2020 - Taylor & Francis
Introduction The human liver is the center for drug metabolism and detoxification and is,
therefore, constantly exposed to toxic chemicals. The loss of liver function as a result of this …

Cross-species comparison of conazole fungicide metabolites using rat and rainbow trout (Onchorhynchus mykiss) hepatic microsomes and purified human CYP 3A4

CS Mazur, JF Kenneke - Environmental science & technology, 2008 - ACS Publications
Ecological risk assessment frequently relies on cross-species extrapolation to predict acute
toxicity from chemical exposures. A major concern for environmental risk characterization is …