[HTML][HTML] More than a feeling: A unified view of stress measurement for population science
Stress can influence health throughout the lifespan, yet there is little agreement about what
types and aspects of stress matter most for human health and disease. This is in part …
types and aspects of stress matter most for human health and disease. This is in part …
Biological age predictors
J Jylhävä, NL Pedersen, S Hägg - EBioMedicine, 2017 - thelancet.com
The search for reliable indicators of biological age, rather than chronological age, has been
ongoing for over three decades, and until recently, largely without success. Advances in the …
ongoing for over three decades, and until recently, largely without success. Advances in the …
Heterogeneous aging across multiple organ systems and prediction of chronic disease and mortality
Biological aging of human organ systems reflects the interplay of age, chronic disease,
lifestyle and genetic risk. Using longitudinal brain imaging and physiological phenotypes …
lifestyle and genetic risk. Using longitudinal brain imaging and physiological phenotypes …
Sex differences in biological aging with a focus on human studies
S Hägg, J Jylhävä - Elife, 2021 - elifesciences.org
Aging is a complex biological process characterized by hallmark features accumulating over
the life course, sha** the individual's aging trajectory and subsequent disease risks. There …
the life course, sha** the individual's aging trajectory and subsequent disease risks. There …
Red blood cell distribution width: a simple parameter with multiple clinical applications
The red blood cell distribution width (RDW) is a simple and inexpensive parameter, which
reflects the degree of heterogeneity of erythrocyte volume (conventionally known as …
reflects the degree of heterogeneity of erythrocyte volume (conventionally known as …
Human telomere biology: a contributory and interactive factor in aging, disease risks, and protection
Telomeres are the protective end-complexes at the termini of eukaryotic chromosomes.
Telomere attrition can lead to potentially maladaptive cellular changes, block cell division …
Telomere attrition can lead to potentially maladaptive cellular changes, block cell division …
Determinants of telomere length across human tissues
K Demanelis, F Jasmine, LS Chen, M Chernoff, L Tong… - Science, 2020 - science.org
INTRODUCTION Telomeres are DNA-protein complexes located at the end of chromosomes
that protect chromosome ends from degradation and fusion. The DNA component of …
that protect chromosome ends from degradation and fusion. The DNA component of …
Leucocyte telomere length and risk of cardiovascular disease: systematic review and meta-analysis
Objective To assess the association between leucocyte telomere length and risk of
cardiovascular disease. Design Systematic review and meta-analysis. Data sources Studies …
cardiovascular disease. Design Systematic review and meta-analysis. Data sources Studies …
Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes
Although several lung cancer susceptibility loci have been identified, much of the heritability
for lung cancer remains unexplained. Here 14,803 cases and 12,262 controls of European …
for lung cancer remains unexplained. Here 14,803 cases and 12,262 controls of European …
TERT—regulation and roles in cancer formation
M Dratwa, B Wysoczańska, P Łacina, T Kubik… - Frontiers in …, 2020 - frontiersin.org
Telomerase reverse transcriptase (TERT) is a catalytic subunit of telomerase. Telomerase
complex plays a key role in cancer formation by telomere dependent or independent …
complex plays a key role in cancer formation by telomere dependent or independent …