Targeting proliferating cell nuclear antigen (PCNA) as an effective strategy to inhibit tumor cell proliferation

M Cardano, C Tribioli, E Prosperi - Current cancer drug targets, 2020 - ingentaconnect.com
Targeting highly proliferating cells is an important issue for many types of aggressive tumors.
Proliferating Cell Nuclear Antigen (PCNA) is an essential protein that participates in a variety …

PCNA: a silent housekeeper or a potential therapeutic target?

SC Wang - Trends in pharmacological sciences, 2014 - cell.com
Proliferating cell nuclear antigen (PCNA) is known as a molecular marker for proliferation
given its role in replication. Three identical molecules of PCNA form a molecular sliding …

A lesson for the maestro of the replication fork: targeting the protein‐binding interface of proliferating cell nuclear antigen for anticancer therapy

VK Bhardwaj, R Purohit - Journal of Cellular Biochemistry, 2022 - Wiley Online Library
The proliferating cell nuclear antigen (PCNA) has emerged as a promising candidate for the
development of novel cancer therapeutics. PCNA is a nononcogenic mediator of DNA …

Tumor necrosis factor receptor 1 is a negative regulator of progenitor proliferation in adult hippocampal neurogenesis

RE Iosif, CT Ekdahl, H Ahlenius, CJH Pronk… - Journal of …, 2006 - jneurosci.org
Tumor necrosis factor-α (TNF-α) is a proinflammatory cytokine, acting through the TNF-R1
and TNF-R2 receptors. The two receptors have been proposed to mediate distinct TNF-α …

Myricitrin exhibits antioxidant, anti-inflammatory and antifibrotic activity in carbon tetrachloride-intoxicated mice

R Domitrović, K Rashed, O Cvijanović… - Chemico-biological …, 2015 - Elsevier
Abstract Myricetin-3-O-α-rhamnoside (myricitrin) is a naturally occurring phenolic compound
which possesses antioxidant and anti-inflammatory activity. The aim of this study was to …

[HTML][HTML] The Role of n-3 Polyunsaturated Fatty Acids in the Prevention and Treatment of Breast Cancer

J Liu, DWL Ma - nutrients, 2014 - mdpi.com
Breast cancer (BC) is the most common cancer among women worldwide. Dietary fatty
acids, especially n-3 polyunsaturated fatty acids (PUFA), are believed to play a role in …

[HTML][HTML] Salvadora persica attenuates DMBA-induced mammary cancer through downregulation oxidative stress, estrogen receptor expression and proliferation and …

AA Hamza, MA Khasawneh, HM Elwy… - Biomedicine & …, 2022 - Elsevier
Naturally occurring phytochemicals especially polyphenolic compounds have received
increasing attention as chemopreventive agents. The chemopreventive potential of the …

[PDF][PDF] The PCNA-RFC families of DNA clamps and clamp loaders

J Majka, PMJ Burgers - Progress in nucleic acid …, 2004 - burgerslab.biochem.wustl.edu
Progress in Nucleic Acid Research Copyright 2004, Elsevier Inc. and Molecular Biology, Vol.
78 227 All rights reserved. 0079-6603/04 $35.00 modeling. Its modification by ubiquitin …

Proteomics study reveals the molecular mechanisms underlying water stress tolerance induced by Piriformospora indica in barley

M Ghabooli, B Khatabi, FS Ahmadi, M Sepehri… - Journal of …, 2013 - Elsevier
Piriformospora indica is a mutualistic root endophytic fungus, which transfers several
benefits to hosts including enhance plant growth and increase yield under both normal and …

Potential of chemically modified hydrophilic surface characteristics to support tissue integration of titanium dental implants

F Schwarz, M Wieland, Z Schwartz… - … Research Part B …, 2009 - Wiley Online Library
In the past, several modifications of specific surface properties such as topography,
structure, chemistry, surface charge, and wettability have been investigated to predictably …