Background Understanding, characterizing, and quantifying human exposures to
environmental chemicals is critical to protect public health. Exposure assessments are key to …

Maternal mortality rates are at an all-time high across the world and are set to increase in
subsequent years. Cardiovascular disease is the leading cause of death during pregnancy …

Background: Animal and human experiments have confirmed sex differences in the
expression of hepatic enzymes that metabolize antipsychotic drugs and that may, in this …

Purpose Antihypertensive drugs are among the most prescribed drugs during pregnancy.
Methyldopa, labetalol, and nifedipine have been perceived safe to use during pregnancy …

Concerns over gestational effects on the disposition of drugs has highlighted the need for a
better understanding of drug distribution and elimination during pregnancy. This study …

Concerns over maternal and fetal drug exposures highlight the need for a better
understanding of drug distribution into the fetus through the placental barrier. This study …

Cell-based test methods with a phenotypic readout are frequently used for toxicity screening.
However, guidance on how to validate the hits and how to integrate this information with …

Perinatal pharmacology is influenced by a myriad of physiological variables that are
changing dynamically. The influence of these covariates has not been assessed …

Physiological changes during pregnancy can alter maternal and fetal drug exposure. The
objective of this work was to predict maternal and umbilical ceftazidime pharmacokinetics …

Ondansetron is commonly used in breastfeeding mothers to treat nausea and vomiting.
There is limited information in humans regarding safety of ondansetron exposure to nursing …