Microfluidics in radiopharmaceutical chemistry

G Pascali, P Watts, PA Salvadori - Nuclear medicine and biology, 2013 - Elsevier
The increased demand for molecular imaging tracers useful in assessing and monitoring
diseases has stimulated research towards more efficient and flexible radiosynthetic routes …

State of the art procedures towards reactive [18F]fluoride in PET tracer synthesis

LYF Haveman, DJ Vugts, AD Windhorst - EJNMMI Radiopharmacy and …, 2023 - Springer
Background Positron emission tomography (PET) is a powerful, non-invasive preclinical and
clinical nuclear imaging technique used in disease diagnosis and therapy assessment …

[HTML][HTML] Microfluidics: a groundbreaking technology for PET tracer production?

C Rensch, A Jackson, S Lindner, R Salvamoser… - Molecules, 2013 - mdpi.com
Application of microfluidics to Positron Emission Tomography (PET) tracer synthesis has
attracted increasing interest within the last decade. The technical advantages of …

Batch-reactor microfluidic device: first human use of a microfluidically produced PET radiotracer

A Lebedev, R Miraghaie, K Kotta, CE Ball, J Zhang… - Lab on a Chip, 2013 - pubs.rsc.org
The very first microfluidic device used for the production of 18F-labeled tracers for clinical
research is reported along with the first human Positron Emission Tomography scan …

18F-labelling innovations and their potential for clinical application

HH Coenen, J Ermert - Clinical and Translational imaging, 2018 - Springer
An impressive variety of new methodologies for the preparation of 18 F-labelled tracers and
ligands has appeared over the last decade. Most strategies of the newly developed …

Radiochemistry on chip: towards dose-on-demand synthesis of PET radiopharmaceuticals

V Arima, G Pascali, O Lade, HR Kretschmer… - Lab on a Chip, 2013 - pubs.rsc.org
We have developed an integrated microfluidic platform for producing 2-[18F]-fluoro-2-deoxy-
D-glucose (18F-FDG) in continuous flow from a single bolus of radioactive isotope solution …

Digital microfluidics: a new paradigm for radiochemistry

PY Keng, RM van Dam - Molecular imaging, 2015 - journals.sagepub.com
The emerging technology of digital microfluidics is opening up the possibility of performing
radiochemistry at the microliter scale to produce tracers for positron emission tomography …

The current role of microfluidics in radiofluorination chemistry

KA Knapp, ML Nickels, HC Manning - Molecular Imaging and Biology, 2020 - Springer
The current utilization of positron emission tomography (PET) imaging is limited due to the
high costs associated with production facility start-up and operations; subsequently, there …

Microfluidic synthesis of radiotracers: recent developments and commercialization prospects

M Mc Veigh, LM Bellan - Lab on a Chip, 2024 - pubs.rsc.org
Positron emission tomography (PET) is a powerful diagnostic tool that holds incredible
potential for clinicians to track a wide variety of biological processes using specialized …

High-efficiency production of radiopharmaceuticals via droplet radiochemistry: A review of recent progress

J Wang, RM van Dam - Molecular imaging, 2020 - journals.sagepub.com
New platforms are enabling radiochemistry to be carried out in tiny, microliter-scale volumes,
and this capability has enormous benefits for the production of radiopharmaceuticals. These …