APOE and Alzheimer's disease: from lipid transport to physiopathology and therapeutics
Alzheimer's disease (AD) is a devastating neurodegenerative disorder characterized by
extracellular amyloid β (Aβ) and intraneuronal tau protein aggregations. One risk factor for …
extracellular amyloid β (Aβ) and intraneuronal tau protein aggregations. One risk factor for …
A quarter century of APOE and Alzheimer's disease: progress to date and the path forward
Alzheimer's disease (AD) is considered a polygenic disorder. This view is clouded, however,
by lingering uncertainty over how to treat the quasi" monogenic" role of apolipoprotein E …
by lingering uncertainty over how to treat the quasi" monogenic" role of apolipoprotein E …
Global estimates on the number of persons across the Alzheimer's disease continuum
Introduction Global estimates on numbers of persons in early stages of Alzheimer's disease
(AD), including prodromal and preclinical, are lacking, yet are needed to inform policy …
(AD), including prodromal and preclinical, are lacking, yet are needed to inform policy …
Frequency of LATE neuropathologic change across the spectrum of Alzheimer's disease neuropathology: Combined data from 13 community-based or population …
Limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-
NC) and Alzheimer's disease neuropathologic change (ADNC) are each associated with …
NC) and Alzheimer's disease neuropathologic change (ADNC) are each associated with …
Menopause impacts human brain structure, connectivity, energy metabolism, and amyloid-beta deposition
All women undergo the menopause transition (MT), a neuro-endocrinological process that
impacts aging trajectories of multiple organ systems including brain. The MT occurs over …
impacts aging trajectories of multiple organ systems including brain. The MT occurs over …
Amyloid precursor protein processing and Alzheimer's disease
RJ O'brien, PC Wong - Annual review of neuroscience, 2011 - annualreviews.org
Alzheimer's disease (AD), the leading cause of dementia worldwide, is characterized by the
accumulation of the β-amyloid peptide (Aβ) within the brain along with hyperphosphorylated …
accumulation of the β-amyloid peptide (Aβ) within the brain along with hyperphosphorylated …
APOE interacts with ACE2 inhibiting SARS-CoV-2 cellular entry and inflammation in COVID-19 patients
Apolipoprotein E (APOE) plays a pivotal role in lipid including cholesterol metabolism. The
APOE ε4 (APOE4) allele is a major genetic risk factor for Alzheimer's and cardiovascular …
APOE ε4 (APOE4) allele is a major genetic risk factor for Alzheimer's and cardiovascular …
[HTML][HTML] APOE genotype and cognition in healthy individuals at risk of Alzheimer's disease: A review
APOE-ε4 is best known as a risk factor for Alzheimer's disease (AD). Consequently, there is
considerable research interest in understanding whether APOE-ε4 influences cognition in …
considerable research interest in understanding whether APOE-ε4 influences cognition in …
Prevalence of apolipoprotein E4 genotype and homozygotes (APOE e4/4) among patients diagnosed with Alzheimer's disease: a systematic review and meta-analysis
A Ward, S Crean, CJ Mercaldi, JM Collins, D Boyd… - …, 2012 - karger.com
Background: Population allele frequencies of apolipoprotein E (APOE) vary by geographic
region. The purpose of this study is to summarize and evaluate published estimates for the …
region. The purpose of this study is to summarize and evaluate published estimates for the …
The Genetic Variability of APOE in Different Human Populations and Its Implications for Longevity
Human longevity is a complex phenotype resulting from the combinations of context-
dependent gene-environment interactions that require analysis as a dynamic process in a …
dependent gene-environment interactions that require analysis as a dynamic process in a …