From archipelago to pandemic battleground: unveiling Indonesia's COVID-19 crisis

BN Harapan, T Harapan, L Theodora… - Journal of epidemiology …, 2023 - Springer
Abstract The coronavirus disease 2019 (COVID-19) pandemic has posed unprecedented
challenges to countries worldwide, including Indonesia. With its unique archipelagic …

Curcumin extraction, isolation, quantification and its application in functional foods: a review with a focus on immune enhancement activities and COVID-19

S Tripathy, DK Verma, M Thakur, AR Patel… - Frontiers in …, 2021 - frontiersin.org
An entirely unknown species of coronavirus (COVID-19) outbreak occurred in December
2019. COVID-19 has already affected more than 180 million people causing~ 3.91 million …

Antiviral phytocompounds “ellagic acid” and “(+)-sesamin” of Bridelia retusa identified as potential inhibitors of SARS-CoV-2 3CL pro using extensive molecular …

AK Umar, JH Zothantluanga, K Aswin, S Maulana… - Structural …, 2022 - Springer
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected billions and
has killed millions to date. Studies are being carried out to find therapeutic molecules that …

In-silico evaluation of natural alkaloids against the main protease and spike glycoprotein as potential therapeutic agents for SARS-CoV-2

M Shah, R Yamin, I Ahmad, G Wu, Z Jahangir… - PLoS …, 2024 - journals.plos.org
Severe Acute Respiratory Syndrome Corona Virus (SARS-CoV-2) is the causative agent of
COVID-19 pandemic, which has resulted in global fatalities since late December 2019 …

Rhamnetin, a nutraceutical flavonoid arrests cell cycle progression of human ovarian cancer (SKOV3) cells by inhibiting the histone deacetylase 2 protein

KK Bharadwaj, B Rabha, I Ahmad… - Journal of …, 2024 - Taylor & Francis
Overexpression of HDAC 2 promotes cell proliferation in ovarian cancer. HDAC 2 is involved
in chromatin remodeling, transcriptional repression, and the formation of condensed …

Benchmarking the ability of novel compounds to inhibit SARS-CoV-2 main protease using steered molecular dynamics simulations

R Singh, VK Bhardwaj, P Das, D Bhattacherjee… - Computers in Biology …, 2022 - Elsevier
Abstract Background The SARS-CoV-2 main protease (M pro) is an attractive target in the
COVID-19 drug development process. It catalyzes the polyprotein's translation from viral …

Identifying plant-derived antiviral alkaloids as dual inhibitors of SARS-CoV-2 main protease and spike glycoprotein through computational screening

R Yamin, I Ahmad, H Khalid, A Perveen… - Frontiers in …, 2024 - frontiersin.org
COVID-19 is currently considered the ninth-deadliest pandemic, spreading through direct or
indirect contact with infected individuals. It has imposed a consistent strain on both the …

Identification of medicinal plant-based phytochemicals as a potential inhibitor for SARS-CoV-2 main protease (Mpro) using molecular docking and deep learning …

A Hossain, ME Rahman, MS Rahman… - Computers in biology …, 2023 - Elsevier
Highly transmissive and rapidly evolving Coronavirus disease-2019 (COVID-19), a viral
disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …

[HTML][HTML] An understanding of coronavirus and exploring the molecular dynamics simulations to find promising candidates against the Mpro of nCoV to combat the …

MB Singh, R Sharma, D Kumar, P Khanna… - Journal of infection and …, 2022 - Elsevier
The first infection case of new coronavirus was reported at the end of 2019 and after then,
the cases are reported in all nations across the world in a very short period. Further, the …

Molecular insights and optimization strategies for the competitive binding of engineered ACE2 proteins: A multiple replica molecular dynamics study

J Sun, X Liu, S Zhang, M Li, Q Zhang… - Physical Chemistry …, 2023 - pubs.rsc.org
The COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus-2
(SARS-CoV-2) continues to spread globally, and rapid viral evolution and the emergence of …