Since antibiotics were first used, each new introduced class has been followed by a global
wave of emergent resistance, largely originating in Europe and North America where they …

Carbapenem-resistant Gram-negative bacteria, in particular the Acinetobacter baumannii-
calcoaceticus complex and Enterobacteriaceae, are escalating global public health threats …

The introduction of antimicrobial drugs in medicine gave hope for a future in which all
infectious diseases could be controlled. Decades later it appears certain this will not be the …

Background. We conducted a national point prevalence survey (PPS) to determine the
prevalence of healthcare-associated infections (HAIs) and antimicrobial use (AMU) in …

ABSTRACT A total of 5,282 bacterial isolates obtained between 1 January and 31
December 31 2008, inclusive, from patients in 10 hospitals across Canada as part of the …

Clinicians need to be aware of the rising problem of resistance in nosocomial and
community-acquired Gram-negative pathogens. Novel agents are urgently needed to …

Purpose: We estimated the prevalence of fluoroquinolone resistant Escherichia coli in
patients undergoing repeat transrectal ultrasound guided prostate needle biopsy and …

The dissemination of antimicrobial resistance (AMR) is an escalating problem and a threat to
public health. Comparative metagenomics was used to investigate the occurrence of …

Polymyxin B and colistin (polymyxin E) are polypeptide antibiotics that were developed in
the 1940s, but fell into disfavor due to their high toxicity rates. These two antibiotics were …

One of the most important resistance mechanisms in Gram-negative bacteria today is the
production of enzymes causing resistance to cephalosporin and carbapenem antibiotics …