Advances in lasso peptide discovery, biosynthesis, and function

SE Barrett, DA Mitchell - Trends in Genetics, 2024 - cell.com
Lasso peptides are a large and sequence-diverse class of ribosomally synthesized and post-
translationally modified peptide (RiPP) natural products characterized by their slip knot-like …

A genomic catalogue of soil microbiomes boosts mining of biodiversity and genetic resources

B Ma, C Lu, Y Wang, J Yu, K Zhao, R Xue… - Nature …, 2023 - nature.com
Soil harbors a vast expanse of unidentified microbes, termed as microbial dark matter,
presenting an untapped reservoir of microbial biodiversity and genetic resources, but has …

Culturing the uncultured microbial majority in activated sludge: a critical review

Y Zhang, T Zhang - Critical Reviews in Environmental Science and …, 2023 - Taylor & Francis
Activated sludge is a widely applied wastewater treatment process that mainly uses
suspended microbial flocs to remove pollutants in wastewater. With the characteristics of …

Nanopore long-read-only metagenomics enables complete and high-quality genome reconstruction from mock and complex metagenomes

L Liu, Y Yang, Y Deng, T Zhang - Microbiome, 2022 - Springer
Background The accurate and comprehensive analyses of genome-resolved metagenomics
largely depend on the reconstruction of reference-quality (complete and high-quality) …

The microbial dark matter and “wanted list” in worldwide wastewater treatment plants

Y Zhang, Y Wang, M Tang, J Zhou, T Zhang - Microbiome, 2023 - Springer
Abstract Background Wastewater treatment plants (WWTPs) are one of the largest
biotechnology applications in the world and are of critical importance to modern urban …

Horizontal transfer potential of antibiotic resistance genes in wastewater treatment plants unraveled by microfluidic-based mini-metagenomics

J Ma, H Sun, B Li, B Wu, X Zhang, L Ye - Journal of Hazardous Materials, 2024 - Elsevier
Wastewater treatment plants (WWTPs) are known to harbor antibiotic resistance genes
(ARGs), which can potentially spread to the environment and human populations. However …

BASALT refines binning from metagenomic data and increases resolution of genome-resolved metagenomic analysis

Z Qiu, L Yuan, CA Lian, B Lin, J Chen, R Mu… - Nature …, 2024 - nature.com
Metagenomic binning is an essential technique for genome-resolved characterization of
uncultured microorganisms in various ecosystems but hampered by the low efficiency of …

Long-read metagenome-assembled genomes improve identification of novel complete biosynthetic gene clusters in a complex microbial activated sludge ecosystem

R Sánchez-Navarro, M Nuhamunada, OS Mohite… - Msystems, 2022 - journals.asm.org
Microorganisms produce a wide variety of secondary/specialized metabolites (SMs), the
majority of which are yet to be discovered. These natural products play multiple roles in …

Genome-centric metagenomics reveals the host-driven dynamics and ecological role of CPR bacteria in an activated sludge system

Y Wang, Y Zhang, Y Hu, L Liu, SJ Liu, T Zhang - Microbiome, 2023 - Springer
Background Candidate phyla radiation (CPR) constitutes highly diverse bacteria with small
cell sizes and are likely obligate intracellular symbionts. Given their distribution and complex …

[HTML][HTML] Metabolic implications for predatory and parasitic bacterial lineages in activated sludge wastewater treatment systems

K Kuroda, S Tomita, H Kurashita, M Hatamoto… - Water Research X, 2023 - Elsevier
Deciphering unclear microbial interactions is key to improving biological wastewater
treatment processes. Microbial predation and parasitism in wastewater treatment …