Genetic and genomic approaches have implicated hundreds of genetic loci in
neurodevelopmental disorders and neurodegeneration, but mechanistic understanding …

Global energy demand and environmental concerns have stimulated increasing efforts to
produce carbon-neutral fuels directly from renewable resources. Microbially derived …

Chromatin immunoprecipitation followed by sequencing (ChIP–seq) is a technique for
genome-wide profiling of DNA-binding proteins, histone modifications or nucleosomes …

Transcriptional regulation is a fundamental molecular mechanism involved in almost every
aspect of life, from homeostasis to development, from metabolism to behavior, from reaction …

Recent advances in technology have led to a dramatic increase in the number of available
transcription factor ChIP-seq and ChIP-chip data sets. Understanding the motif content of …

Abstract MEME (Multiple EM for Motif Elicitation) is one of the most widely used tools for
searching for novel 'signals' in sets of biological sequences. Applications include the …

A common question within the context of de novo motif discovery is whether a newly
discovered, putative motif resembles any previously discovered motif in an existing …