Indole represents one of the most important privileged scaffolds in drug discovery. Indole
derivatives have the unique property of mimicking the structure of peptides and to bind …

Traditionally, the organic chemist has increased complexity in a molecule by the stepwise
formation of individual bonds. It would be more efficient if several bonds could be …

The viral enzyme integrase is essential for the replication of human immunodeficiency virus
type 1 (HIV-1) and represents a remaining target for antiretroviral drugs. Here, we describe …

Rhodium (II) perfluorobutyrate-mediated decomposition of vinyl azides provides a new, mild
entry into Rh2 (II) nitrenoid chemistry. This methodology allows rapid access to a variety of …

We have identified two N-phenyl-N′-(2, 2, 6, 6-tetramethyl-piperidin-4-yl)-oxalamide
analogs as a novel class of human immunodeficiency virus type 1 (HIV-1) entry inhibitors …

Indole-derived radical cations, open-shell reactive species, display distinctive dual reactivity
due to the carbon-centered radical and more electrophilic carbocation, which frequently …

Using a training set of diketo-like acid HIV-1 integrase (IN) strand-transfer inhibitors, a 3D
pharmacophore model was derived having quantitative predictive ability in terms of activity …

Integration of a desossiribonucleic acid (DNA) copy of the viral ribonucleic acid (RNA) into
host genomes is a fundamental step in the replication cycle of all retroviruses. The highly …

Human immunodeficiency virus type 1 (HIV-1) integrase is a crucial target for antiretroviral
drugs, and several keto− enol acid class (often referred to as diketo acid class) inhibitors …

Several fatal bunyavirus infections lack specific treatment. Here, we show that diketo acids
engage a panel of bunyavirus cap-snatching endonucleases, inhibit their catalytic activity …