Polymeric delivery of therapeutic nucleic acids

R Kumar, CF Santa Chalarca, MR Bockman… - Chemical …, 2021 - ACS Publications
The advent of genome editing has transformed the therapeutic landscape for several
debilitating diseases, and the clinical outlook for gene therapeutics has never been more …

Poly (ethylene glycol) alternatives in biomedical applications

X Yao, C Qi, C Sun, F Huo, X Jiang - Nano Today, 2023 - Elsevier
Abstract Poly (ethylene glycol)(PEG) as gold standard has been extensively conjugated to
diagnostic and therapeutic agents or decorated on the surface of nanoplatforms, which is …

Hyaluronic acid for anticancer drug and nucleic acid delivery

F Dosio, S Arpicco, B Stella, E Fattal - Advanced drug delivery reviews, 2016 - Elsevier
Hyaluronic acid (HA) is widely used in anticancer drug delivery, since it is biocompatible,
biodegradable, non-toxic, and non-immunogenic; moreover, HA receptors are …

Hyaluronic acid-based nanocarriers for anticancer drug delivery

CP Fu, XY Cai, SL Chen, HW Yu, Y Fang, XC Feng… - Polymers, 2023 - mdpi.com
Hyaluronic acid (HA), a main component of the extracellular matrix, is widely utilized to
deliver anticancer drugs due to its biocompatibility, biodegradability, non-toxicity, non …

Hyaluronic acid-based biopharmaceutical delivery and tumor-targeted drug delivery system

G Huang, H Huang - Journal of Controlled Release, 2018 - Elsevier
Hyaluronic acid (HA) is a natural polysaccharide with good biocompatibility and
degradability. HA and its derivatives can be used as sustained-release carriers for drugs …

Folate receptor‐mediated delivery of Cas9 RNP for enhanced immune checkpoint disruption in cancer cells

Y Lin, U Wilk, J Pöhmerer, E Hörterer, M Höhn, X Luo… - Small, 2023 - Wiley Online Library
The clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR‐
associated protein 9 (Cas9) system offers great opportunities for the treatment of numerous …

Strategies to overcome the polycation dilemma in drug delivery

A Bernkop-Schnürch - Advanced drug delivery reviews, 2018 - Elsevier
Because of polycationic auxiliary agents such as chitosan, polyethyleneimine and cell
penetrating peptides as well as cationic lipids assembling to polycationic systems, drug …

Bioinert, stealth or interactive: how surface chemistry of nanocarriers determines their fate in vivo

JD Friedl, V Nele, G De Rosa… - Advanced functional …, 2021 - Wiley Online Library
Nanocarriers (NCs) have emerged as powerful tools to improve drug solubility, to promote
drug transport across membranes, to protect their payload from premature degradation, and …

CD44 targeting biocompatible and biodegradable hyaluronic acid cross-linked zein nanogels for curcumin delivery to cancer cells: In vitro and in vivo evaluation

HY Seok, NS Re**old, KM Lekshmi… - Journal of Controlled …, 2018 - Elsevier
In this study, we developed novel hyaluronic acid cross-linked zein nanogels (HA-Zein NGs)
to deliver the potential anticancer agent curcumin (CRC), a naturally occurring …

Carbohydrate-based nanocarriers and their application to target macrophages and deliver antimicrobial agents

T Mosaiab, DC Farr, MJ Kiefel, TA Houston - Advanced drug delivery …, 2019 - Elsevier
Many deadly infections are produced by microorganisms capable of sustained survival in
macrophages. This reduces exposure to chemadrotherapy, prevents immune detection, and …