Prenatal and early postnatal life represent key periods of immune system development. In
addition to genetics and host biology, environment has a large and irreversible role in the …

Worldwide 300 million children and adults are affected by asthma. The development of
asthma is influenced by environmental and other exogenous factors synergizing with …

Background Childhood asthma incidence is decreasing in some parts of Europe and North
America. Antibiotic use in infancy has been associated with increased asthma risk. In the …

Background Antibiotics are amongst the most commonly used drugs in children. In addition
to inducing antibiotic resistance, antibiotic exposure has been associated with adverse long …

Clinicians handle a growing amount of clinical, biometric, and biomarker data. In this “big
data” era, there is an emerging faith that the answer to all clinical and scientific questions …

Background Few studies have examined longitudinal asthma incidence rates (IRs) from a
public health surveillance perspective. Objective Our aim was to calculate descriptive …

Background Early-life exposures to antibiotics may increase the risk of develo** childhood
asthma. However, little is known about the mechanisms linking antibiotic exposures to …

The spread of antimicrobial resistance genes (ARGs) is a major public health crisis, with the
ongoing spread of ARGs leading to reduced efficacy of antibiotic treatments. The gut …

Asthma is a complex heterogeneous disease. The neutrophilic subtypes of asthma are
described as persistent, more severe and corticosteroid-resistant, with higher hospitalization …

Background Early-life severe respiratory syncytial virus (RSV) bronchiolitis is a risk factor for
childhood asthma. Because azithromycin may attenuate airway inflammation during RSV …