Abnormal enzymatic activities are directly related to the development of cancers. Identifying
the location and expression levels of these enzymes in live cancer cells have considerable …

For a long time, cysteine cathepsins were considered primarily as proteases crucial for
nonspecific bulk proteolysis in the endolysosomal system. However, this view has …

The main protease (Mpro) of SARS-CoV-2 is a key antiviral drug target. While most Mpro
inhibitors have a γ-lactam glutamine surrogate at the P1 position, we recently found that …

Major histocompatibility complex II (MHC II) molecules play a vital role in the onset and
control of cellular immunity. In a highly selective process, MHC II presents peptides derived …

Personalized cancer vaccines targeting patient-specific neoantigens are a promising cancer
treatment modality; however, neoantigen physicochemical variability can present challenges …

Lysosomes remain powerful organelles and important targets for cancer therapy because
cancer cell proliferation is greatly dependent on effective lysosomal function. Recent studies …

Coronaviruses are a large group of enveloped, single-stranded positive-sense RNA viruses
that infect a wide range of avian and mammalian species, including humans. The …

Chromogenic and fluorogenic probes may be described as the reagents that can interact
with analytes (targets) accompanied by the changes of their spectroscopic (chromogenic, or …

Lysosomes and lysosomal hydrolases, including the cathepsins, have been shown to
change their properties with aging brain a long time ago, although their function was not …

TMPRSS2 is an androgen-regulated cell-surface serine protease expressed predominantly
in prostate epithelium. TMPRSS2 is expressed highly in localized high-grade prostate …