Colorectal cancer (CRC) is the third most common cancer and has a high metastasis and
reoccurrence rate. Long noncoding RNAs (lncRNAs) play an important role in CRC growth …

phosphoinositide-dependent protein kinase 1 (PDK1) is considered as master kinase
regulating AGC kinase family members such as AKT, SGK, PLK, S6K and RSK. Although …

Cancers with loss-of-function mutations in BRCA1 or BRCA2 are deficient in the DNA
damage repair pathway called homologous recombination (HR), rendering these cancers …

Resistance against conventional chemotherapeutic agents is one of the main reasons for
tumor relapse and poor clinical outcomes in cancer patients. Various mechanisms are …

Serum and glucocorticoid-induced protein kinase 1 (SGK1) is a member of the “AGC”
subfamily of protein kinases, which shares structural and functional similarities with the AKT …

Objective Exosomes have been documented to function in human diseases, yet their
transfer of microRNA (miRNA) in preeclampsia (PE) has seldom been reported. This study …

Glucocorticoids (GCs) are a central component of multi-drug treatment protocols against T
and B acute lymphoblastic leukemia (ALL), which are used intensively during the remission …

Abstract Background/Aims: Doxorubicin (DOX) is a widely used chemotherapeutic agent for
colorectal cancer (CRC). However, the acquirement of DOX resistance limits its clinical …

Abstract Background Glioblastoma Multiforme is the deadliest type of brain tumor and is
characterized by very poor prognosis with a limited overall survival. Current optimal …

Loss of integrin-mediated attachment to extracellular matrix (ECM) proteins can trigger a
variety of cellular changes that affect cell viability. Foremost among these is the activation of …