Polymer translocation and nanopore sequencing: a review of advances and challenges

SL Singh, K Chauhan, AS Bharadwaj… - International Journal of …, 2023 - mdpi.com
Various biological processes involve the translocation of macromolecules across
nanopores; these pores are basically protein channels embedded in membranes …

Single-polymer dynamics under constraints: scaling theory and computer experiment

A Milchev - Journal of Physics: Condensed Matter, 2011 - iopscience.iop.org
The relaxation, diffusion and translocation dynamics of single linear polymer chains in
confinement is briefly reviewed with emphasis on the comparison between theoretical …

Sequence dependence of DNA translocation through a nanopore

K Luo, T Ala-Nissila, SC Ying, A Bhattacharya - Physical Review Letters, 2008 - APS
We investigate the dynamics of DNA translocation through a nanopore using 2D Langevin
dynamics simulations, focusing on the dependence of the translocation dynamics on the …

Polymer translocation through α-hemolysin pore with tunable polymer-pore electrostatic interaction

CTA Wong, M Muthukumar - The Journal of chemical physics, 2010 - pubs.aip.org
We have measured the ionic current blockages produced by single molecules of sodium
poly (styrene sulfonate) passing through an α-hemolysin protein pore under an electric field …

Modeling the separation of macromolecules: A review of current computer simulation methods

GW Slater, C Holm, MV Chubynsky… - …, 2009 - Wiley Online Library
Abstract Theory and numerical simulations play a major role in the development of improved
and novel separation methods. In some cases, computer simulations predict counterintuitive …

Driven polymer translocation through nanopores: Slow-vs.-fast dynamics

K Luo, T Ala-Nissila, SC Ying, R Metzler - Europhysics letters, 2010 - iopscience.iop.org
We investigate the dynamics of polymer translocation through nanopores under external
driving by 3D Langevin Dynamics simulations, focusing on the scaling of the average …

Influence of non-universal effects on dynamical scaling in driven polymer translocation

T Ikonen, A Bhattacharya, T Ala-Nissila… - The Journal of chemical …, 2012 - pubs.aip.org
We study the dynamics of driven polymer translocation using both molecular dynamics (MD)
simulations and a theoretical model based on the non-equilibrium tension propagation on …

Mutant pores

J Clarke, AJ Heron, L Jayasinghe, EJ Wallace… - US Patent …, 2017 - Google Patents
US9751915B2 - Mutant pores - Google Patents US9751915B2 - Mutant pores - Google
Patents Mutant pores Download PDF Info Publication number US9751915B2 …

Method for sequencing a heteropolymeric target nucleic acid sequence

D Stoddart, AJ Heron, G Maglia, JHP Bayley - US Patent 9,732,381, 2017 - Google Patents
The invention relates to a method for sequencing a heteropolymeric target nucleic acid
sequence that involves stochastic sensing. The invention also relates to a method for …

Mechanism of KCl enhancement in detection of nonionic polymers by nanopore sensors

CG Rodrigues, DC Machado, SF Chevtchenko… - Biophysical journal, 2008 - cell.com
The mechanisms of KCl-induced enhancement in identification of individual molecules of
poly (ethylene glycol) using solitary α-hemolysin nanoscale pores are described. The …