Summary Hypoxia-inducible factor (HIF), a central regulator for detecting and adapting to
cellular oxygen levels, transcriptionally activates genes modulating oxygen homeostasis …

Angiogenesis is a complex physiological process. However, over the past couple of
decades, abnormally accelerated or pathological angiogenesis has garnered greater …

Poor wound healing and pathological healing have been pressing issues in recent years, as
they impact human quality of life and pose risks of long-term complications. The study of …

Cardiovascular disease (CVD) is the leading cause of death worldwide, and extensive
research has been performed to understand this disease better, using various experimental …

Hypoxic tumor microenvironment is a common feature of solid tumors and is associated with
aggressiveness and poor patient outcomes. A continuous interference between cancer cells …

Research showing that microRNAs (miRNAs) are versatile regulators of gene expression
has instigated tremendous interest in cardiovascular research. The overwhelming majority of …

Mycobacterium tuberculosis (Mtb) survives in macrophages by evading delivery to the
lysosome and promoting the accumulation of lipid bodies, which serve as a bacterial source …

Plaque microvascularization and increased endothelial permeability are key players in the
development of atherosclerosis, from the initial stages of plaque formation to the occurrence …

Platelets play a crucial role in the maintenance of hemostasis, as well as in thrombosis.
Upon activation, platelets release small membrane-bound microparticles (MPs) containing …

Hypoxia, or low oxygen tension, is a unique environmental stress that induces global
changes in a complex regulatory network of transcription factors and signaling proteins to …