Latency is a state of cryptic viral infection associated with genomic persistence and highly
restricted gene expression. Its hallmark is reversibility: under appropriate circumstances …

Gammaherpesviruses are lymphotropic viruses that are associated with the development of
lymphoproliferative diseases, lymphomas, as well as other nonlymphoid cancers. Most …

During their productive cycle, herpesviruses exhibit a strictly regulated temporal cascade of
gene expression that can be divided into three general stages: immediate-early (IE), early …

Herpesviruses constitute a family of large DNA viruses widely spread in vertebrates and
causing a variety of different diseases. They possess dsDNA genomes ranging from 120 to …

A conserved herpesviral kinase, designated ORF36 in murine γ-herpesvirus 68 (MHV-68),
plays multiple vital roles in the viral life cycle. Here, we show by screening mutant viruses …

DNA virus infection can elicit the DNA damage response in host cells, including ATM kinase
activation and H2AX phosphorylation. This is considered to be the host cell response to …

DNA signature tags (molecular barcodes) facilitate functional screens by identifying mutants
in mixed populations that have a reduced or increased adaptation to a particular …

RIG-I is a pattern recognition receptor that senses viral RNA and is crucial for host innate
immune defense. Here, we describe a mechanism of RIG-I activation through …

The herpesviridae are a large family of DNA viruses with large and complicated genomes.
Genetic manipulation and the generation of recombinant viruses have been extremely …

During lytic replication, herpesviruses express their genes in a temporal cascade
culminating in expression of “late” genes. Two subfamilies of herpesviruses, the beta-and …