Implication of Pyrethroid Neurotoxicity for Human Health: A Lesson from Animal Models

MO Oyovwi, AD Atere, P Chimwuba, UG Joseph - Neurotoxicity Research, 2025 - Springer
Pyrethroids, synthetic insecticides used in pest management, pose health risks, particularly
neurotoxic effects, with studies linking exposure to a neurodegenerative disorder. This …

Exposure to Environmental Pesticides and the Risk of Autism Spectrum Disorders: A Population-Based Case-Control Study

P Román, C Ruiz-González, L Rueda-Ruzafa… - Medicina, 2024 - mdpi.com
Background and Objectives: Autism spectrum disorder (ASD) is a neurodevelopmental
condition characterized by challenges in communication, social interactions, and repetitive …

[HTML][HTML] Environmental exposure to common pesticide induces synaptic deficit and social memory impairment driven by neurodevelopmental vulnerability of …

J Di Re, L Koff, Y Avchalumov, AK Singh… - Journal of Hazardous …, 2025 - Elsevier
Environmental exposure to pesticides at levels deemed safe by regulatory agencies has
been linked to increased risk for neurodevelopmental disorders. Yet, the mechanisms …

A preliminary estimate of the environmental burden of disease associated with exposure to pyrethroid insecticides and ADHD in Europe based on human …

A Purece, ST Thomsen, D Plass, A Spyropoulou… - Environmental …, 2024 - Springer
Human biomonitoring (HBM) data indicate that exposure to pyrethroids is widespread in
Europe, with significantly higher exposure observed in children compared to adults …

[HTML][HTML] Cyfluthrin exposure during pregnancy causes neurotoxicity in offspring—Ca2+ overload via IP3R-GRP75-VDAC1 pathway

H Gao, M Tian, X Geng, J Zhao, Y Song, B Wu… - Ecotoxicology and …, 2024 - Elsevier
Cyfluthrin (Cy) is a widely used pyrethroid insecticide. There is growing evidence that Cy
can cause damage to the nervous, reproductive, and immune systems, but there is limited …

Developmental pyrethroid exposure disrupts molecular pathways for MAP kinase and circadian rhythms in mouse brain

JH Nguyen, MA Curtis, AS Imami, WG Ryan… - …, 2024 - pmc.ncbi.nlm.nih.gov
Neurodevelopmental disorders (NDDs) are a category of pervasive disorders of the
develo** nervous system with few or no recognized biomarkers. A significant portion of …

Developmental pyrethroid exposure disrupts molecular pathways for circadian rhythms and synaptic plasticity in mouse brain.

JH Nguyen, MA Curtis, AS Imami, WG Ryan… - Biorxiv: the Preprint …, 2023 - europepmc.org
Neurodevelopmental disorders (NDDs) are a category of pervasive disorders of the
develo** nervous system with few or no recognized biomarkers. A significant portion of …

[HTML][HTML] Developmental pyrethroid exposure in mouse leads to disrupted brain metabolism in adulthood

MA Curtis, N Saferin, JH Nguyen, AS Imami, WG Ryan… - NeuroToxicology, 2024 - Elsevier
Environmental and genetic risk factors, and their interactions, contribute significantly to the
etiology of neurodevelopmental disorders (NDDs). Recent epidemiology studies have …

The pyrethroid insecticide deltamethrin disrupts neuropeptide and monoamine signaling pathways in the gastrointestinal tract

AC White, IN Krout, S Mouhi, J Chang, SD Kelly… - bioRxiv, 2024 - biorxiv.org
Enteroendocrine cells (EECs) are a rare cell type of the intestinal epithelium. Various
subtypes of EECs produce distinct repertoires of monoamines and neuropeptides which …

Folate prevents the autism-related phenotype caused by developmental pyrethroid exposure in prairie voles

N Saferin, I Haseeb, AM Taha, SE Beecroft, S Pillai… - bioRxiv, 2024 - biorxiv.org
Neurodevelopmental disorders (NDDs) have dramatically increased in prevalence to an
alarming one in six children, and yet both causes and preventions remain elusive. Recent …