Chagas disease: from discovery to a worldwide health problem

KCF Lidani, FA Andrade, L Bavia… - Frontiers in public …, 2019 - frontiersin.org
Carlos Chagas discovered American trypanosomiasis, also named Chagas disease (CD) in
his honor, just over a century ago. He described the clinical aspects of the disease …

Trypanosoma cruzi genetic diversity: Something new for something known about Chagas disease manifestations, serodiagnosis and drug sensitivity

B Zingales - Acta tropica, 2018 - Elsevier
The genetic diversity of Trypanosoma cruzi, the protozoan agent of Chagas disease, is
widely recognized. At present, T. cruzi is partitioned into seven discrete ty** units (DTUs) …

Bats as 'special'reservoirs for emerging zoonotic pathogens

CE Brook, AP Dobson - Trends in microbiology, 2015 - cell.com
The ongoing West African Ebola epidemic highlights a recurring trend in the zoonotic
emergence of virulent pathogens likely to come from bat reservoirs that has caused …

1, 3, 4-Thiadiazole: synthesis, reactions, and applications in medicinal, agricultural, and materials chemistry

Y Hu, CY Li, XM Wang, YH Yang, HL Zhu - Chemical reviews, 2014 - ACS Publications
Over the past decades, the bulk of chemists' interests have been on heterocyclic compounds
and their various derivatives as well as their applications in the pharmaceutical and …

Trypanosoma cruzi transmission in the wild and its most important reservoir hosts in Brazil

AM Jansen, SCC Xavier, ALR Roque - Parasites & vectors, 2018 - Springer
Abstract Trypanosoma cruzi (Kinetoplastea: Trypanosomatidae) infects all tissues of its
hosts, which along with humans, include hundreds of mammalian species in the Americas …

Parasite zoonoses and wildlife: one health, spillover and human activity

RCA Thompson - International journal for parasitology, 2013 - Elsevier
This review examines parasite zoonoses and wildlife in the context of the One Health triad
that encompasses humans, domestic animals, wildlife and the changing ecosystems in …

Trypanosoma cruzi genetic diversity: impact on transmission cycles and Chagas disease

B Zingales, DC Bartholomeu - Memórias do instituto oswaldo cruz, 2022 - SciELO Brasil
Trypanosoma cruzi, the agent of Chagas disease (ChD), exhibits remarkable biological and
genetic diversity, along with eco-epidemiological complexity. In order to facilitate …

Genetic diversity of Trypanosoma cruzi in bats, and multilocus phylogenetic and phylogeographical analyses supporting Tcbat as an independent DTU (discrete …

L Lima, O Espinosa-Álvarez, PA Ortiz, JA Trejo-Varón… - Acta tropica, 2015 - Elsevier
Trypanosoma cruzi is a complex of phenotypically and genetically diverse isolates
distributed in six discrete ty** units (DTUs) designated as TcI–TcVI. Five years ago, T …

The history of Chagas disease

D Steverding - Parasites & vectors, 2014 - Springer
The ancestor of Trypanosome cruzi was probably introduced to South American via bats
approximately 7-10 million years ago. When the first humans arrived in the New World, a …

Evasion of the Immune Response by Trypanosoma cruzi during Acute Infection

MS Cardoso, JL Reis-Cunha… - Frontiers in …, 2016 - frontiersin.org
Trypanosoma cruzi is the etiologic agent of Chagas disease, a neglected tropical disease
that affects millions of people mainly in Latin America. To establish a life-long infection, T …