STAT3 and its targeting inhibitors in oral squamous cell carcinoma

M Jiang, B Li - Cells, 2022 - mdpi.com
Oral squamous cell carcinoma (OSCC) usually originates from the precancerous lesions of
oral mucosa and accounts for approximately 90% of oral cancers. Current therapeutic …

Glioma-associated microglia/macrophages (GAMs) in glioblastoma: Immune function in the tumor microenvironment and implications for immunotherapy

C Lin, N Wang, C Xu - Frontiers in Immunology, 2023 - frontiersin.org
Glioma is a mixed solid tumor composed of neoplastic and non-neoplastic components.
Glioma-associated macrophages and microglia (GAMs) are crucial elements of the glioma …

Radiotherapy of high-grade gliomas: dealing with a stalemate

G Frosina - Critical Reviews in Oncology/Hematology, 2023 - Elsevier
This article discusses the studies on radiotherapy of high-grade gliomas published between
January 1, 2022, and June 30, 2022, with special reference to their molecular biology basis …

Glioblastoma therapy: past, present and future

E Obrador, P Moreno-Murciano… - International journal of …, 2024 - mdpi.com
Glioblastoma (GB) stands out as the most prevalent and lethal form of brain cancer.
Although great efforts have been made by clinicians and researchers, no significant …

Structure, function, signaling pathways and clinical therapeutics: The translational potential of STAT3 as a target for cancer therapy

D Shi, J Tao, S Man, N Zhang, L Ma, L Guo… - … et Biophysica Acta (BBA …, 2024 - Elsevier
Cancer remains one of the most difficult human diseases to overcome because of its
complexity and diversity. Signal transducers and transcriptional activators 3 (STAT3) protein …

'Slicing'glioblastoma drivers with the Swiss cheese model

OYT Pumar, JD Lathia, DC Watson, D Bayik - Trends in cancer, 2024 - cell.com
The Swiss cheese model is used to assess risks and explain accidents in a variety of
industries. This model can be applied to dissect the homeostatic mechanisms whose …

Molecular pathways and genomic landscape of glioblastoma stem cells: opportunities for targeted therapy

AM Hersh, H Gaitsch, S Alomari, D Lubelski, BM Tyler - Cancers, 2022 - mdpi.com
Simple Summary Glioblastoma stem cells are a unique population of tumor cells that
contribute to tumor growth, invasion, and resistance to chemotherapy and radiation therapy …

Multimodal neuro-nanotechnology: Challenging the existing paradigm in glioblastoma therapy

S Kudruk, CM Forsyth, MZ Dion… - Proceedings of the …, 2024 - National Acad Sciences
Integrating multimodal neuro-and nanotechnology-enabled precision immunotherapies with
extant systemic immunotherapies may finally provide a significant breakthrough for …

Sestrin2 provides cerebral protection through activation of Nrf2 signaling in microglia following subarachnoid hemorrhage

Y Yang, H Ding, C Yang, J Wu, Y Bao, S Lan… - Frontiers in …, 2023 - frontiersin.org
Subarachnoid hemorrhage (SAH) is a neurological emergency characterized by
dysfunctional inflammatory response. However, no effective therapeutic options have been …

Small molecular inhibitors and degraders targeting STAT3 for cancer therapy: An updated review (from 2022 to 2024)

Z Kang, S Li, Y Li, J Song, Y Peng, Y Chen - Chinese Chemical Letters, 2024 - Elsevier
Signal transducer and activator of transcription 3 (STAT3) is a member of the transcription
factors involved in regulating many physiological and pathological processes, such as cell …