Clinical endpoints are essential for assessing the safety and efficacy of new cancer
therapies. They are used by oncologists to help guide clinical decision making. While overall …

The measurement and treatment of acute pain in animals is essential from a welfare
perspective. Valid pain-related outcome measures are also crucial for ensuring reliable and …

Extreme weather events radically alter ecosystems. When ecological damage persists,
selective pressures on individuals can change, leading to phenotypic adjustments. For …

Many clinical trials involve following patients for a long time. The primary event of interest in
those studies is death, relapse, adverse drug reaction or development of a new disease. The …

Objective The safety of potentially inappropriate medications (PIMs) in elderly patients is still
debated. Using the PRISCUS list, we examined the incident all-cause hospitalization risk …

Background Dementia is a complex disorder characterized by poor outcomes for the
patients and high costs of care. After decades of research little is known about its …

Background Controversy exists about the incremental utility of nontraditional lipid
biomarkers [eg, apolipoprotein (apo) B, apo AI, and non-HDL-C] in improving cardiovascular …

Clinical time-to-event studies are dependent on large sample sizes, often not available at a
single institution. However, this is countered by the fact that, particularly in the medical field …

Responding to the urgent necessity for improved worker safety under rising global
temperatures, this study proposes adaptive work/rest schedules tailored for varied …

Immuno-oncologics (IOs) differ from chemotherapies as they prime the patient's immune
system to attack the tumor, rather than directly destroying cancer cells. The IO mechanism of …