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[HTML][HTML] Sodium-glucose cotransporter-2 inhibitors and their potential role in dementia onset and cognitive function in patients with diabetes mellitus: a systematic …
This systematic review and meta-analysis aimed to determine the association between the
use of sodium-glucose cotransporter 2 (SGLT-2) inhibitors and dementia onset as well as …
use of sodium-glucose cotransporter 2 (SGLT-2) inhibitors and dementia onset as well as …
The potential anti-arrhythmic effect of SGLT2 inhibitors
Sodium-glucose cotransporter type 2 inhibitors (SGLT2i) were initially recommended as oral
anti-diabetic drugs to treat type 2 diabetes (T2D), by inhibiting SGLT2 in proximal tubule and …
anti-diabetic drugs to treat type 2 diabetes (T2D), by inhibiting SGLT2 in proximal tubule and …
[HTML][HTML] Empagliflozin mitigates cardiac hypertrophy through cardiac RSK/NHE-1 inhibition
Background SGLT2i reduce cardiac hypertrophy, but underlying mechanisms remain
unknown. Here we explore a role for serine/threonine kinases (STK) and sodium hydrogen …
unknown. Here we explore a role for serine/threonine kinases (STK) and sodium hydrogen …
Empagliflozin prevents heart failure through inhibition of the NHE1-NO pathway, independent of SGLT2
Sodium glucose cotransporter 2 inhibitors (SGLT2i) constitute the only medication class that
consistently prevents or attenuates human heart failure (HF) independent of ejection …
consistently prevents or attenuates human heart failure (HF) independent of ejection …
Role and molecular mechanisms of SGLT2 inhibitors in pathological cardiac remodeling
B Chen, J Guo, H Ye, X Wang… - Molecular Medicine …, 2024 - spandidos-publications.com
Cardiovascular diseases are caused by pathological cardiac remodeling, which involves
fibrosis, inflammation and cell dysfunction. This includes autophagy, apoptosis, oxidative …
fibrosis, inflammation and cell dysfunction. This includes autophagy, apoptosis, oxidative …
Impact of common ALDH2 inactivating mutation and alcohol consumption on Alzheimer's disease
Aldehyde dehydrogenase 2 (ALDH2) is an enzyme found in the mitochondrial matrix that
plays a central role in alcohol and aldehyde metabolism. A common ALDH2 polymorphism …
plays a central role in alcohol and aldehyde metabolism. A common ALDH2 polymorphism …
The interplay between sodium/glucose cotransporter type 2 and mitochondrial ionic environment
G Borriello, V Buonincontri, A de Donato, M Della Corte… - Mitochondrion, 2024 - Elsevier
Mitochondrial volume is maintained through the permeability of the inner mitochondrial
membrane by a specific aquaporin and the osmotic balance between the mitochondrial …
membrane by a specific aquaporin and the osmotic balance between the mitochondrial …
Endothelial dysfunction in psoriasis: an integrative review
Q Li, B Pang, E Dang, G Wang - Journal of Investigative Dermatology, 2024 - Elsevier
Vascular endothelial cells (ECs), the inner layer of blood vessels, were previously
considered to be a passive lining that facilitates cellular and molecular exchange. However …
considered to be a passive lining that facilitates cellular and molecular exchange. However …
Clinical trials in-a-dish for cardiovascular medicine
Cardiovascular diseases persist as a global health challenge that requires methodological
innovation for effective drug development. Conventional pipelines relying on animal models …
innovation for effective drug development. Conventional pipelines relying on animal models …
Harnessing human genetics and stem cells for precision cardiovascular medicine
Human induced pluripotent stem cell (iPSC) platforms are valuable for biomedical and
pharmaceutical research by providing tissue-specific human cells that retain patients' …
pharmaceutical research by providing tissue-specific human cells that retain patients' …