▪ Abstract The events leading to transcription of eukaryotic protein-coding genes culminate
in the positioning of RNA polymerase II at the correct initiation site. The core promoter, which …

In eukaryotes, the core promoter serves as a platform for the assembly of transcription
preinitiation complex (PIC) that includes TFIIA, TFIIB, TFIID, TFIIE, TFIIF, TFIIH, and RNA …

Mammalian promoters can be separated into two classes, conserved TATA box–enriched
promoters, which initiate at a well-defined site, and more plastic, broad and evolvable CpG …

We introduce cap analysis gene expression (CAGE), which is based on preparation and
sequencing of concatamers of DNA tags deriving from the initial 20 nucleotides from 5′ end …

The development, growth, and survival of eukaryotic organisms require the proper
regulation of tens of thousands of genes. By complex formulae that have yet to be solved …

By analyzing 1,780,295 5′-end sequences of human full-length cDNAs derived from 164
kinds of oligo-cap cDNA libraries, we identified 269,774 independent positions of …

The core promoter of eukaryotic genes is the minimal DNA region that recruits the basal
transcription machinery to direct efficient and accurate transcription initiation. The fraction of …

Background The core promoter, a region of about 100 base-pairs flanking the transcription
start site (TSS), serves as the recognition site for the basal transcription apparatus …

The CCAAT box promoter element and NF-Y, the transcription factor (TF) that binds to it,
were among the first cis-elements and trans-acting factors identified; their interplay is …

Evidence supports a critical role for microRNAs (miRNAs) in regulation of tissue-specific
differentiation and development. Signifying a disruption of these programs, expression …