Alzheimer's disease is a neurological disorder that results in cognitive and behavioral
impairment. Conventional treatment strategies, such as acetylcholinesterase inhibitor drugs …

Depression is less prevalent among older adults than among younger adults, but it can have
serious consequences. More than half of cases represent a first onset in later life. Although …

Objective: To understand the role of depressive symptoms in preclinical Alzheimer's
disease, it is essential to define their temporal relationship to Alzheimer's proteinopathies in …

Neuropsychiatric symptoms (NPS) are core features of Alzheimer's disease and related
dementias. Once thought to emerge primarily in people with late-stage disease, these …

Importance Neuropsychiatric syndromes (NPSs) are common in neurodegenerative
disorders (NDDs); compromise the quality of life of patients and their care partners; and are …

Depression is perhaps the most frequent cause of emotional suffering in later life and
significantly decreases quality of life in older adults. In recent years, the literature on late-life …

ContextMild cognitive impairment (MCI) may be a precursor to dementia, at least in some
cases. Dementia and MCI are associated with neuropsychiatric symptoms in clinical …

In elderly people, depression mainly affects those with chronic medical illnesses and
cognitive impairment, causes suffering, family disruption, and disability, worsens the …

Neuropsychiatric symptoms (NPS) are very common in Alzheimer's disease (AD),
particularly agitation, apathy, depression, and delusions. Brain networks or circuits …

Background The use of antidepressants in dementia accompanied by depressive symptoms
is widespread, but their clinical efficacy is uncertain. This review updates an earlier version …