Type 2 diabetes (T2D) is a metabolic disorder characterized by hyperglycemia and insulin
resistance in which oxidative stress is thought to be a primary cause. Considering that …

Mitochondria are well known as the centre of energy metabolism in eukaryotic cells.
However, they can not only generate ATP through the tricarboxylic acid cycle and oxidative …

Mitochondria are critical organelles for endocrine health; steroid hormone biosynthesis
occurs in these organelles and they provide energy in the form of ATP for hormone …

Disruption of the most fundamental cellular energy process, the mitochondrial respiratory
chain, results in a diverse and variable group of multisystem disorders known collectively as …

Mitochondrial disease is one of the most common groups of genetic diseases with a
minimum prevalence of greater than 1 in 5000 in adults. Whilst multi-system involvement is …

Mitochondrial diabetes (MD) is generally classified as a genetic defect of β-cells. The main
pathophysiology is insulin secretion failure in pancreatic β-cells due to impaired …

Primary mitochondrial diseases refer to a group of heterogeneous and complex genetic
disorders affecting 1: 5000 people. The true prevalence is anticipated to be even higher …

Endocrine dysfunction in mitochondrial disease is commonplace, but predominantly
restricted to disease of the endocrine pancreas resulting in diabetes mellitus. Other …

All forms of diabetes share the common etiology of insufficient pancreatic β-cell function to
meet peripheral insulin demand. In pancreatic β-cells, mitochondria serve to integrate the …

Mitochondrial diseases are a group of common inherited diseases causing disruption of
oxidative phosphorylation. Some patients with mitochondrial disease have endocrine …