A review of the clinical side effects of bone morphogenetic protein-2

AW James, G LaChaud, J Shen, G Asatrian… - … Engineering Part B …, 2016‏ - liebertpub.com
Bone morphogenetic protein-2 (BMP-2) is currently the only Food and Drug Administration
(FDA)-approved osteoinductive growth factor used as a bone graft substitute. However, with …

A review of fibrin and fibrin composites for bone tissue engineering

A Noori, SJ Ashrafi, R Vaez-Ghaemi… - International journal …, 2017‏ - Taylor & Francis
Tissue engineering has emerged as a new treatment approach for bone repair and
regeneration seeking to address limitations associated with current therapies, such as …

Bioactive coatings for orthopaedic implants—recent trends in development of implant coatings

BGX Zhang, DE Myers, GG Wallace, M Brandt… - International journal of …, 2014‏ - mdpi.com
Joint replacement is a major orthopaedic procedure used to treat joint osteoarthritis. Aseptic
loosening and infection are the two most significant causes of prosthetic implant failure. The …

Nano-hydroxyapatite composite biomaterials for bone tissue engineering—a review

J Venkatesan, SK Kim - Journal of biomedical nanotechnology, 2014‏ - ingentaconnect.com
In recent years, significant development has been achieved in the construction of artificial
bone with ceramics, polymers and metals. Nano-hydroxyapatite (nHA) is widely used …

Studies of bone morphogenetic protein-based surgical repair

KWH Lo, BD Ulery, KM Ashe, CT Laurencin - Advanced drug delivery …, 2012‏ - Elsevier
Over the past several decades, recombinant human bone morphogenetic proteins (rhBMPs)
have been the most extensively studied and widely used osteoinductive agents for clinical …

Tissue engineered bone using select growth factors: A comprehensive review of animal studies and clinical translation studies in man.

D Gothard, EL Smith, JM Kanczler… - European cells & …, 2014‏ - livrepository.liverpool.ac.uk
There is a growing socio-economic need for effective strategies to repair damaged bone
resulting from disease, trauma and surgical intervention. Bone tissue engineering has …

Cranial bone defects: current and future strategies

C Szpalski, J Barr, M Wetterau, PB Saadeh… - Neurosurgical …, 2010‏ - thejns.org
Bony defects in the craniomaxillofacial skeleton remain a major and challenging health
concern. Surgeons have been trying for centuries to restore functionality and aesthetic …

Biomimetic delivery with micro‐and nanoparticles

SC Balmert, SR Little - Advanced materials, 2012‏ - Wiley Online Library
The nascent field of biomimetic delivery with micro‐and nanoparticles (MNP) has advanced
considerably in recent years. Drawing inspiration from the ways that cells communicate in …

From natural bone grafts to tissue engineering therapeutics: brainstorming on pharmaceutical formulative requirements and challenges

B Baroli - Journal of pharmaceutical sciences, 2009‏ - Elsevier
Tissue engineering is an emerging multidisciplinary field of investigation focused on the
regeneration of diseased or injured tissues through the delivery of appropriate molecular …

The stimulation of healing within a rat calvarial defect by mPCL–TCP/collagen scaffolds loaded with rhBMP-2

AA Sawyer, SJ Song, E Susanto, P Chuan, CXF Lam… - Biomaterials, 2009‏ - Elsevier
Bone morphogenetic proteins (BMPs) have been widely investigated for their clinical use in
bone repair and it is known that a suitable carrier matrix to deliver them is essential for …