The advent of clustered regularly interspaced short palindromic repeat (CRISPR) genome
editing, coupled with advances in computing and imaging capabilities, has initiated a new …

Over the past decade, CRISPR has become as much a verb as it is an acronym,
transforming biomedical research and providing entirely new approaches for dissecting all …

Plasma membrane rupture (PMR) is the final cataclysmic event in lytic cell death. PMR
releases intracellular molecules known as damage-associated molecular patterns (DAMPs) …

CRISPR/Cas9 genome editing has gained rapidly increasing attentions in recent years,
however, the translation of this biotechnology into therapy has been hindered by efficient …

Cytosolic protein delivery offers opportunities to develop protein-based therapeutics
specifically modulate intracellular processes, especially those linked to 'undruggable'targets …

Gene editing is a versatile technique in biomedicine that promotes fundamental research as
well as clinical therapy. The development of Clustered Regularly Interspaced Short …

Genome-wide sequencing has led to the discovery of thousands of long non-coding RNA
(lncRNA) loci in the human genome, but evidence of functional significance has remained …

Rett syndrome (RTT), a severe postnatal neurodevelopmental disorder, is caused by
mutations in the X-linked gene encoding methyl-CpG-binding protein 2 (MeCP2). MeCP2 is …

Astrocytes strongly promote the formation and maturation of synapses by secreted proteins.
Several astrocyte-secreted synaptogenic proteins controlling excitatory synapse …

Retrotransposons mediate gene regulation in important developmental and pathological
processes. Here, we characterized the transient retrotransposon induction during …