For approval, a proposed generic drug product must demonstrate it is bioequivalent (BE) to
the reference listed drug product. For locally acting drug products, conventional BE …

The objectives of this study were to expand and implement a Computational Fluid Dynamics
(CFD)-Dissolution, Absorption and Clearance (DAC)-Pharmacokinetics (PK) multi-physics …

Nasal sprays, which produce relatively large pharmaceutical droplets and have high
momentum, are primarily used to deliver locally acting drugs to the nasal mucosa …

The nasopharynx, at the back of the nose, constitutes the dominant initial viral infection
trigger zone along the upper respiratory tract. However, as per the standard recommended …

Computational fluid dynamics (CFD) has been used to investigate the intranasal deposition
of corticosteroid sprays. CFD Lagrangian tracking models terminate particle motion once …

Validating numerical models against experimental models of nasal spray deposition is
challenging since many aspects must be considered. That being said, it is a critical step in …

Nasal sprays are typically characterized using in vitro spray metrics such as spray cone
angle and droplet size distribution. It is currently not clear how these in vitro metrics correlate …

Intranasal corticosteroid sprays (ICSs) are frequently prescribed for allergic rhinitis (AR),
which is the fifth most common chronic disease in the United States. This study aimed to …

Purpose The objective of this study was to incorporate a passive cyclic loading strategy into
the infant air-jet dry powder inhaler (DPI) in a manner that provides high efficiency aerosol …

Human studies provide valuable information on components or analytes recovered from
exhaled breath, but there are limitations due to inter-individual and intra-individual variation …