The Mycobacterium tuberculosis complex (MTBC) consists of closely related species that
cause tuberculosis in both humans and animals. This illness, still today, remains to be one of …

The genus Mycobacterium is best known for its two major pathogenic species, M.
tuberculosis and M. leprae, the causative agents of two of the world's oldest diseases …

Background Mycobacterium tuberculosis (Mtb) becomes dormant and phenotypically drug
resistant when it encounters multiple stresses within the host. Inability of currently available …

The human tuberculous granuloma provides the morphological framework for local immune
processes central to the outcome of tuberculosis. This review article describes investigations …

A central feature of Mycobacterium tuberculosis (Mtb) pathogenesis is the ability of Mtb to
survive within macrophages (MØ). Despite its critical importance, our appreciation of the …

Once across the barrier of the epithelium, macrophages constitute the primary defense
against microbial invasion. For most microbes, the acidic, hydrolytically competent …

Infectious diseases caused by clinically important Mycobacteria continue to be an important
public health problem worldwide primarily due to emergence of drug resistance crisis. In …

Intracellular pathogens such as Mycobacterium tuberculosis have evolved strategies for
co** with the pressures encountered inside host cells. The ability to coordinate global …

One of the challenges in clinical infectious diseases is the problem of chronic infections,
which can require long durations of antibiotic treatment and often recur. An emerging …

Tuberculosis exerts a tremendous burden on global health, with∼ 9 million new infections
and∼ 2 million deaths annually. The Mycobacterium tuberculosis complex (MTC) was …