Physiology of astroglia

A Verkhratsky, M Nedergaard - Physiological reviews, 2018‏ - journals.physiology.org
Astrocytes are neural cells of ectodermal, neuroepithelial origin that provide for homeostasis
and defense of the central nervous system (CNS). Astrocytes are highly heterogeneous in …

Mitochondria, energy, and metabolism in neuronal health and disease

D Trigo, C Avelar, M Fernandes, J Sá… - FEBS …, 2022‏ - Wiley Online Library
Mitochondria are associated with various cellular activities critical to homeostasis,
particularly in the nervous system. The plastic architecture of the mitochondrial network and …

How does adenosine control neuronal dysfunction and neurodegeneration?

RA Cunha - Journal of neurochemistry, 2016‏ - Wiley Online Library
The adenosine modulation system mostly operates through inhibitory A1 (A1R) and
facilitatory A2A receptors (A2AR) in the brain. The activity‐dependent release of adenosine …

Astrocytes monitor cerebral perfusion and control systemic circulation to maintain brain blood flow

N Marina, IN Christie, A Korsak, M Doronin… - Nature …, 2020‏ - nature.com
Astrocytes provide neurons with essential metabolic and structural support, modulate
neuronal circuit activity and may also function as versatile surveyors of brain milieu, tuned to …

The effects of microglia‐and astrocyte‐derived factors on neurogenesis in health and disease

T Araki, Y Ikegaya, R Koyama - European Journal of …, 2021‏ - Wiley Online Library
Hippocampal neurogenesis continues throughout life and has been suggested to play an
essential role in maintaining spatial cognitive function under physiological conditions. An …

ATP mediates rapid microglial response to local brain injury in vivo

D Davalos, J Grutzendler, G Yang, JV Kim, Y Zuo… - Nature …, 2005‏ - nature.com
Parenchymal microglia are the principal immune cells of the brain. Time-lapse two-photon
imaging of GFP-labeled microglia demonstrates that the fine termini of microglial processes …

Astrocytes as secretory cells of the central nervous system: idiosyncrasies of vesicular secretion

A Verkhratsky, M Matteoli, V Parpura, JP Mothet… - The EMBO …, 2016‏ - embopress.org
Astrocytes are housekeepers of the central nervous system (CNS) and are important for
CNS development, homeostasis and defence. They communicate with neurones and other …

Gap junctions

MS Nielsen, LN Axelsen, PL Sorgen… - Comprehensive …, 2012‏ - pmc.ncbi.nlm.nih.gov
Gap junctions are essential to the function of multicellular animals, which require a high
degree of coordination between cells. In vertebrates, gap junctions comprise connexins and …

ATP synthesis and storage

M Bonora, S Patergnani, A Rimessi, E De Marchi… - Purinergic …, 2012‏ - Springer
Since 1929, when it was discovered that ATP is a substrate for muscle contraction, the
knowledge about this purine nucleotide has been greatly expanded. Many aspects of cell …

[HTML][HTML] Physiology, adenosine triphosphate

J Dunn, MH Grider - 2020‏ - europepmc.org
The body is a complex organism, and as such, it takes energy to maintain proper
functioning. Adenosine triphosphate (ATP) is the source of energy for use and storage at the …