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Gluconeogenesis in cancer: function and regulation of PEPCK, FBPase, and G6Pase
Cancer cells display a high rate of glycolysis in the presence of oxygen to promote
proliferation. Gluconeogenesis, the reverse pathway of glycolysis, can antagonize aerobic …
proliferation. Gluconeogenesis, the reverse pathway of glycolysis, can antagonize aerobic …
Catalpol ameliorates hepatic insulin resistance in type 2 diabetes through acting on AMPK/NOX4/PI3K/AKT pathway
Type 2 diabetes is characterized by insulin resistance in target tissues and hyperglycemia.
Catalpol is a natural product isolated from the root of Rehmannia glutinosa, which has been …
Catalpol is a natural product isolated from the root of Rehmannia glutinosa, which has been …
Differential impact of flavonoids on redox modulation, bioenergetics, and cell signaling in normal and tumor cells: a comprehensive review
Significance: Flavonoids can interact with multiple molecular targets to elicit their cellular
effects, leading to changes in signal transduction, gene expression, and/or metabolism …
effects, leading to changes in signal transduction, gene expression, and/or metabolism …
MiR-494 induces metabolic changes through G6pc targeting and modulates sorafenib response in hepatocellular carcinoma
Background Metabolic reprogramming is a well-known marker of cancer, and it represents
an early event during hepatocellular carcinoma (HCC) development. The recent approval of …
an early event during hepatocellular carcinoma (HCC) development. The recent approval of …
Pomegranate peel anthocyanins prevent diet-induced obesity and insulin resistance in association with modulation of the gut microbiota in mice
Purpose Pomegranate peels are rich in anthocyanins. The present study aimed to explore
the beneficial effects of pomegranate peel anthocyanins (PPA) on obesity and gut …
the beneficial effects of pomegranate peel anthocyanins (PPA) on obesity and gut …
The transcriptional corepressor CtBP2 serves as a metabolite sensor orchestrating hepatic glucose and lipid homeostasis
M Sekiya, K Kainoh, T Sugasawa, R Yoshino… - Nature …, 2021 - nature.com
Biological systems to sense and respond to metabolic perturbations are critical for the
maintenance of cellular homeostasis. Here we describe a hepatic system in this context …
maintenance of cellular homeostasis. Here we describe a hepatic system in this context …
Glucose-6–phosphatase is a key metabolic regulator of glioblastoma invasion
Glioblastoma (GBM) remains the most aggressive primary brain cancer in adults. Similar to
other cancers, GBM cells undergo metabolic reprogramming to promote proliferation and …
other cancers, GBM cells undergo metabolic reprogramming to promote proliferation and …
Impaired hypoxia-inducible factor (HIF) regulation by hyperglycemia
The mechanisms that contribute to the development of diabetes complications remain
unclear. A defective reaction of tissues to hypoxia has recently emerged as a new …
unclear. A defective reaction of tissues to hypoxia has recently emerged as a new …
[HTML][HTML] Microarray-predicted marker genes and molecular pathways indicating crowding stress in rainbow trout (Oncorhynchus mykiss)
A Rebl, M Zebunke, A Borchel, R Bochert, M Verleih… - Aquaculture, 2017 - Elsevier
Stocking density is considered as a key factor determining the productivity of fish
aquaculture systems. The transcriptomic response to crowding stress is, however, still poorly …
aquaculture systems. The transcriptomic response to crowding stress is, however, still poorly …
SH2 domain-containing inositol 5-phosphatase (SHIP2) inhibition ameliorates high glucose-induced de-novo lipogenesis and VLDL production through regulating …
Hepatic de-novo lipogenesis and production of triglyceride rich very low density lipoprotein
(VLDL) is increased in the state of insulin resistance, however, the role of a negative …
(VLDL) is increased in the state of insulin resistance, however, the role of a negative …