Immunity to malaria has been linked to the availability and function of helper CD4+ T cells,
cytotoxic CD8+ T cells and γδ T cells that can respond to both the asymptomatic liver stage …

Malaria, caused by infection with Plasmodium parasites, drives multiple regulatory
responses across the immune landscape. These regulatory responses help to protect …

STING is an innate immune cytosolic adaptor for DNA sensors that engage malaria parasite
(Plasmodium falciparum) or other pathogen DNA. As P. falciparum infects red blood cells …

Control of intracellular parasites responsible for malaria requires host IFN-γ+ T-bet+ CD4+ T
cells (Th1 cells) with IL-10 produced by Th1 cells to mitigate the pathology induced by this …

Interferon lambdas (IFN-λs; IFNL1-4) modulate immunity in the context of infections and
autoimmune diseases, through a network of induced genes. IFN-λs act by binding to the …

Plasmodium parasite–specific antibodies are critical for protection against malaria, yet the
development of long-lived and effective humoral immunity against Plasmodium takes many …

IL-10 produced by CD4+ T cells suppresses inflammation by inhibiting T cell functions and
the upstream activities of antigen presenting cells (APCs). IL-10 was first identified in Th2 …

Controlled human malaria infection (CHMI) entails deliberate infection with malaria
parasites either by mosquito bite or by direct injection of sporozoites or parasitized …

Clinical immunity against Plasmodium falciparum infection develops in residents of malaria
endemic regions, manifesting in reduced clinical symptoms during infection and in …

Infection by malaria parasites (Plasmodium spp.) remains one of the leading causes of
morbidity and mortality, especially in tropical regions of the world. Despite the availability of …