The hidden Markov models are statistical models used in many real-world applications and
communities. The use of hidden Markov models has become predominant in the last …

Noncoding DNA regions have central roles in human biology, evolution, and disease.
ChromHMM helps to annotate the noncoding genome using epigenomic information across …

Algorithms that accurately predict gene structure from primary sequence alone were
transformative for annotating the human genome. Can we also predict the expression levels …

Chromatin organization plays a critical role in cellular function by regulating access to
genetic information. However, understanding chromatin folding is challenging due to its …

We report SPIN, an integrative computational method to reveal genome-wide intranuclear
chromosome positioning and nuclear compartmentalization relative to multiple nuclear …

Transcription is regulated by transcription factor (TF) binding at promoters and distal
regulatory elements and histone modifications that control the accessibility of these …

Transcriptional enhancers play a key role in the initiation and maintenance of gene
expression programmes, particularly in metazoa. How these elements control their target …

Regulatory elements are the genomic regions that interact with transcription factors to
control cell-type-specific gene expression in different cellular environments. A precise and …

Most behaviors such as making tea are not stereotypical but have an obvious structure.
However, analytical methods to objectively extract structure from non-stereotyped behaviors …

Segmentation and genome annotation (SAGA) algorithms are widely used to understand
genome activity and gene regulation. These algorithms take as input epigenomic datasets …