Despite the high long-term survival in localized prostate cancer, metastatic prostate cancer
remains largely incurable even after intensive multimodal therapy. The lethality of advanced …

Tripartite motif (TRIM) family proteins, most of which have E3 ubiquitin ligase activities, have
various functions in cellular processes including intracellular signaling, development …

Comprehensive genomic characterization of prostate cancer has identified recurrent
alterations in genes involved in androgen signaling, DNA repair, and PI3K signaling, among …

Stat6 is known to drive macrophage M2 polarization. However, how macrophage
polarization is fine-tuned by Stat6 is poorly understood. Here, we find that Lys383 of Stat6 is …

In the past few years, it has become clear that mutations in epigenetic regulatory genes are
common in human cancers. Therapeutic strategies are now being developed to target …

Androgen receptor (AR) is a ligand-responsive transcription factor that drives terminal
differentiation of the prostatic luminal epithelia. By contrast, in tumors originating from these …

The addressable pocket of a protein is often not functionally relevant in disease. This is true
for the multidomain, bromodomain-containing transcriptional regulator TRIM24. TRIM24 has …

Long noncoding RNAs (lncRNAs) play important roles in regulating the development and
progression of many cancers. However, the clinical significance of specific lncRNAs in the …

Despite remarkable clinical efficacy of immune checkpoint blockade (ICB) in cancer
treatment, ICB benefits for triple-negative breast cancer (TNBC) remain limited. Through …

Targeting the androgen receptor (AR) signaling axis has been, over decades, the mainstay
of prostate cancer therapy. More potent inhibitors of androgen synthesis and antiandrogens …