White adipose tissue, once regarded as morphologically and functionally bland, is now
recognized to be dynamic, plastic and heterogenous, and is involved in a wide array of …

Obesity is a major health problem that affects millions of individuals, and it is associated with
metabolic diseases including insulin resistance (IR), type 2 diabetes (T2D), and …

Classic hormone membrane receptors, such as leucine-rich repeat-containing G protein–
coupled receptor (LGR) 1 (follicle-stimulating hormone receptor), LGR2 (luteinizing hormone …

For any given level of overall adiposity, individuals vary considerably in fat distribution. The
inherited basis of fat distribution in the general population is not fully understood. Here, we …

Over the past 15 years, genome-wide association studies (GWASs) have generated a
wealth of new information. Larger samples sizes, refined phenotypes and higher-resolution …

Insulin resistance causes multiple epidemic metabolic diseases, including type 2 diabetes,
cardiovascular disease, and fatty liver, but is not routinely measured in epidemiological …

Healthy adipose tissue remodeling depends on the balance between de novo adipogenesis
from adipogenic progenitor cells and the hypertrophy of adipocytes. De novo adipogenesis …

The 'diabetic bone paradox'suggested that type 2 diabetes (T2D) patients would have higher
areal bone mineral density (BMD) but higher fracture risk than individuals without T2D. In …

Wnt signaling is an ancient and evolutionarily conserved pathway with fundamental roles in
the development of adipose tissues. Roles of this pathway in mesenchymal stem cell fate …

Familial partial lipodystrophy (FPLD) is a heterogenous group of syndromes associated with
a high prevalence of cardiometabolic diseases. Prior work has proposed DEXA-derived fat …