Liver regeneration is a complex process involving the crosstalk of multiple cell types,
including hepatocytes, hepatic stellate cells, endothelial cells and inflammatory cells. The …

Our view on liver macrophages in the context of health and disease has been reformed by
the recognition of a remarkable heterogeneity of phagocytes in the liver. Liver macrophages …

Macrophages are key regulators of liver fibrosis progression and regression in nonalcoholic
steatohepatitis (NASH). Liver macrophages comprise resident phagocytes, Kupffer cells …

Overexpressed extracellular matrix (ECM) in pancreatic ductal adenocarcinoma (PDAC)
limits drug penetration into the tumor and is associated with poor prognosis. Here, we …

Liver fibrosis is a clinically significant finding that has major impacts on patient morbidity and
mortality. The mechanism of fibrosis involves many different cellular pathways, but the major …

Myofibroblasts are activated in response to tissue injury with the primary task to repair lost or
damaged extracellular matrix. Enhanced collagen secretion and subsequent contraction …

The importance of proper skin wound healing becomes evident when our body's repair
mechanisms fail, leading to either non-healing (chronic) wounds or excessive repair …

Recently, the need for more standardized operation procedures in experimental liver fibrosis
research was suggested due to dramatic changes in European animal welfare rules. Here …

Hepatic fibrosis is a wound healing response to insults and as such affects the entire world
population. In industrialized countries, the main causes of liver fibrosis include alcohol …

In most vertebrates, the liver produces bile that is necessary to emulsify absorbed fats and
enable the digestion of lipids in the small intestine as well as to excrete bilirubin and other …